{"metadata":{"accession":"PF02754","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR004017","hierarchy":null,"name":{"name":"Cysteine-rich domain","short":"CCG"},"description":[{"text":"<p>The key element of this domain is the CX31-38CCX33-34CXXC sequence motif normally found at the C-terminus in archaeal and bacterial Hdr-like proteins [[cite:PUB00109129]]. There may be one or two copies, and the motif is probably an iron-sulfur binding cluster. In some instances one of the cysteines is replaced by an aspartate, and aspartate can in principle also function as a ligand of an iron-sulfur cluster [[cite:PUB00109129]]. The entry includes a subunit from heterodisulphide reductase and a subunit from glycolate oxidase ([swissprot:P52074]) [[cite:PUB00007282]] and glycerol-3-phosphate dehydrogenase.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00109129":{"PMID":11952791,"ISBN":null,"volume":"269","issue":"7","year":2002,"title":"Purification and characterization of a membrane-bound enzyme complex from the sulfate-reducing archaeon Archaeoglobus fulgidus related to heterodisulfide reductase from methanogenic archaea.","URL":null,"raw_pages":"1895-904","medline_journal":"Eur J Biochem","ISO_journal":"Eur J Biochem","authors":["Mander GJ","Duin EC","Linder D","Stetter KO","Hedderich R."],"DOI_URL":null},"PUB00007282":{"PMID":8606183,"ISBN":null,"volume":"178","issue":"7","year":1996,"title":"glc locus of Escherichia coli: characterization of genes encoding the subunits of glycolate oxidase and the glc regulator protein.","URL":null,"raw_pages":"2051-9","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Pellicer MT","Badia J","Aguilar J","Baldoma L."],"DOI_URL":"http://jb.asm.org/cgi/content/abstract/178/7/2051"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":142,"interactions":0,"matches":67945,"pathways":0,"proteins":37412,"proteomes":14229,"sets":0,"structural_models":{"alphafold":23792},"structures":19,"taxa":20217},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":57,"alignment:full":34564},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8rwn","name":"CryoEM structure of the Hdr(ABC)2 subunits of the Elp-Hdr complex of Methanothermobacter marburgensis"}}}