{"metadata":{"accession":"PF02720","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003870","hierarchy":null,"name":{"name":"Domain of unknown function (DUF222)","short":"DUF222"},"description":[{"text":"<p>This family is often found associated to the N-terminus of the HNH endonuclease domain [pfam:PF01844]. The function of this domain is uncertain. This family has been called the 13E12 repeat family [[cite:PUB00057273]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00057273":{"PMID":12029045,"ISBN":null,"volume":"184","issue":"12","year":2002,"title":"Definition of the mycobacterial SOS box and use to identify LexA-regulated genes in Mycobacterium tuberculosis.","URL":null,"raw_pages":"3287-95","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Davis EO","Dullaghan EM","Rand L."],"DOI_URL":"http://dx.doi.org/10.1128/JB.184.12.3287-3295.2002"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":37,"interactions":0,"matches":19420,"pathways":0,"proteins":18467,"proteomes":2216,"sets":0,"structural_models":{"alphafold":11207},"structures":0,"taxa":2801},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":9055},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}