{"metadata":{"accession":"PF02698","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003848","hierarchy":null,"name":{"name":"DUF218 domain","short":"DUF218"},"description":[{"text":"<p>This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain (Bateman A pers. obs). The entry includes SanA [swissprot:P33017] and Sfix ([swissprot:O33790]) from Salmonella typhimurium which are involved in Vancomycin resistance [[cite:PUB00019464]]. These proteins may be involved in murein synthesis [[cite:PUB00019465]]. This domain is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified [[cite:PUB00050945]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00019465":{"PMID":9738879,"ISBN":null,"volume":"259","issue":"1","year":1998,"title":"The sfiX, rfe and metN genes of Salmonella typhimurium and their involvement in the His(c) pleiotropic response.","URL":null,"raw_pages":"46-53","medline_journal":"Mol Gen Genet","ISO_journal":"Mol. Gen. Genet.","authors":["Mouslim C","Cano DA","Casadesus J."],"DOI_URL":"http://dx.doi.org/10.1007/s004380050787"},"PUB00050945":{"PMID":18393394,"ISBN":null,"volume":"72","issue":"1","year":2008,"title":"The Escherichia coli YdcF binds S-adenosyl-L-methionine and adopts an alpha/beta-fold characteristic of nucleotide-utilizing enzymes.","URL":null,"raw_pages":"506-9","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Chao KL","Lim K","Lehmann C","Doseeva V","Howard AJ","Schwarz FP","Herzberg O."],"DOI_URL":"http://dx.doi.org/10.1002/prot.22046"},"PUB00019464":{"PMID":8550448,"ISBN":null,"volume":"178","issue":"1","year":1996,"title":"Amplification of a novel gene, sanA, abolishes a vancomycin-sensitive defect in Escherichia coli.","URL":null,"raw_pages":"94-102","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Rida S","Caillet J","Alix JH."],"DOI_URL":"http://jb.asm.org/cgi/content/abstract/178/1/94"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":92,"interactions":0,"matches":25685,"pathways":0,"proteins":25685,"proteomes":14217,"sets":0,"structural_models":{"alphafold":15881},"structures":1,"taxa":20830},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":376,"alignment:full":12223},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}