{"metadata":{"accession":"PF02696","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003846","hierarchy":null,"name":{"name":"Protein adenylyltransferase SelO","short":"SelO"},"description":[{"text":"<p>SelO and its homologues are widespread among most eukaryotic taxa, and are also common in many major bacterial taxa. SelO is a conserved pseudokinase that transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation). It contains a protein kinase fold with ATP flipped in the active site [[cite:PUB00092455]]. In eukaryotes, it is a mitochondrial protein that may be involved in redox biology [[cite:PUB00092456]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00092455":{"PMID":30270044,"ISBN":null,"volume":"175","issue":"3","year":2018,"title":"Protein AMPylation by an Evolutionarily Conserved Pseudokinase.","URL":null,"raw_pages":"809-821.e19","medline_journal":"Cell","ISO_journal":"Cell","authors":["Sreelatha A","Yee SS","Lopez VA","Park BC","Kinch LN","Pilch S","Servage KA","Zhang J","Jiou J","Karasiewicz-Urbanska M","Lobocka M","Grishin NV","Orth K","Kucharczyk R","Pawlowski K","Tomchick DR","Tagliabracci VS."],"DOI_URL":"https://doi.org/10.1016/j.cell.2018.08.046"},"PUB00092456":{"PMID":24751718,"ISBN":null,"volume":"9","issue":"4","year":2014,"title":"Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein.","URL":null,"raw_pages":"e95518","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Han SJ","Lee BC","Yim SH","Gladyshev VN","Lee SR."],"DOI_URL":"https://doi.org/10.1371/journal.pone.0095518"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":74,"interactions":0,"matches":14895,"pathways":0,"proteins":14609,"proteomes":12188,"sets":0,"structural_models":{"alphafold":10025},"structures":8,"taxa":20440},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":44,"alignment:full":8545},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6lna","name":"YdiU complex with AMPNPP and Mn2+"}}}