{"metadata":{"accession":"PF02676","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003827","hierarchy":null,"name":{"name":"Methyltransferase TYW3","short":"TYW3"},"description":[{"text":"<p>The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis [[cite:PUB00044611]].  yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA.  TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner [[cite:PUB00044611]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044611":{"PMID":16642040,"ISBN":null,"volume":"25","issue":"10","year":2006,"title":"Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.","URL":null,"raw_pages":"2142-54","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Noma A","Kirino Y","Ikeuchi Y","Suzuki T."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7601105"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":82,"interactions":0,"matches":3172,"pathways":0,"proteins":3105,"proteomes":2533,"sets":0,"structural_models":{"alphafold":2640},"structures":6,"taxa":6632},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":130,"alignment:full":2472},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2it2","name":"Structure of PH1069 protein from Pyrococcus horikoshii"}}}