MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor [[cite:PUB00064727]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Manganese_exporter","extract":"The Manganese (Mn2+) Exporter (MntP) Family is a member of the Lysine Exporter (LysE) Superfamily. The MntP family is a small family whose members have been found in bacteria and archaea. MntP proteins are of about 200 amino acyl residues with 6 putative transmembrane segments (TMSs). The Conserved Domain Database (CDD) recognized two DUF204 repeats, each repeat having 3 TMSs. A representative list of proteins belonging to the MntP family can be found in the Transporter Classification Database.
","thumbnail":null}],"literature":{"PUB00064727":{"PMID":21908668,"ISBN":null,"volume":"193","issue":"21","year":2011,"title":"The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis.","URL":null,"raw_pages":"5887-97","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Waters LS","Sandoval M","Storz G."],"DOI_URL":"http://dx.doi.org/10.1128/JB.05872-11"}},"set_info":{"accession":"CL0292","name":"LysE"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":8099,"pathways":0,"proteins":6974,"proteomes":4717,"sets":1,"structural_models":{"alphafold":4558},"structures":0,"taxa":7605},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":53,"alignment:full":4306},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}