YcaO is an ATP- an Mg2+-binding protein involved in the peptidic biosynthesis of azoline. There three motifs involved in the binding are, in UniProtKB:P75838, 71-79: Sx3ExxER, 184-203: Sx6Ex3Qx3ExxER, and 286-290: RxxxE. Three slightly different functional families are represented in this family, proteins involved in TOMM (thiazole/oxazole-modified microcin) biogenesis, non-TOMM proteins such as UniProtKB:P75838, and TfuA-associated non-TOMM proteins involved in trifolitoxin biosynthesis. UniProtKB:P75838 hydrolyses ATP to AMP and pyrophosphate [[cite:PUB00078765]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"YcaO","extract":"YcaO is a protein found in bacteria which is involved in the synthesis of thiazole/oxazole modified microcin antibiotics, such as bottromycin. YcaO performs ATP dependent cyclodehydration to form the oxazole and thiazole moieties of the microcin.
","thumbnail":null}],"literature":{"PUB00078765":{"PMID":25129028,"ISBN":null,"volume":"10","issue":"10","year":2014,"title":"Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis.","URL":null,"raw_pages":"823-9","medline_journal":"Nat Chem Biol","ISO_journal":"Nat. Chem. Biol.","authors":["Dunbar KL","Chekan JR","Cox CL","Burkhart BJ","Nair SK","Mitchell DA."],"DOI_URL":"http://dx.doi.org/10.1038/nchembio.1608"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":59,"interactions":0,"matches":8814,"pathways":0,"proteins":8762,"proteomes":6003,"sets":0,"structural_models":{"alphafold":5234},"structures":16,"taxa":8712},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":181,"alignment:full":3799},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6peu","name":"Structure of YcaO enzyme from Methanocaldococcus jannaschii in complex with peptide"}}}