{"metadata":{"accession":"PF02616","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003768","hierarchy":null,"name":{"name":"Segregation and condensation protein ScpA","short":"SMC_ScpA"},"description":[{"text":"<p>This is a family of proteins that from part of the condensin complex that regulates chromosome segregation.  This is the A subunit, which binds to the ScpB subunit, [pfam:PF04079], and SMC, [pfam:PF02463], to participate in chromosomal partition during cell division [[cite:PUB00109191],[cite:PUB00109192]]. The condensin complex pulls DNA away from the mid-cell into both cell halves [[cite:PUB00020315]]. These proteins are part of the Kleisin superfamily.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00109192":{"PMID":23541893,"ISBN":null,"volume":"21","issue":"4","year":2013,"title":"Molecular basis of SMC ATPase activation: role of internal structural changes of the regulatory subcomplex ScpAB.","URL":null,"raw_pages":"581-94","medline_journal":"Structure","ISO_journal":"Structure","authors":["Kamada K","Miyata M","Hirano T."],"DOI_URL":null},"PUB00020315":{"PMID":12667442,"ISBN":null,"volume":"11","issue":"3","year":2003,"title":"Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.","URL":null,"raw_pages":"571-5","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Schleiffer A","Kaitna S","Maurer-Stroh S","Glotzer M","Nasmyth K","Eisenhaber F."],"DOI_URL":"http://dx.doi.org/10.1016/S1097-2765(03)00108-4"},"PUB00109191":{"PMID":23353789,"ISBN":null,"volume":"20","issue":"3","year":2013,"title":"An asymmetric SMC-kleisin bridge in prokaryotic condensin.","URL":null,"raw_pages":"371-9","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Burmann F","Shin HC","Basquin J","Soh YM","Gimenez-Oya V","Kim YG","Oh BH","Gruber S."],"DOI_URL":null}},"set_info":{"accession":"CL0157","name":"Kleisin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":14810,"pathways":0,"proteins":14767,"proteomes":14601,"sets":1,"structural_models":{"alphafold":9617},"structures":7,"taxa":20656},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":7801},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5h66","name":"Crystal structure of the Bacillus subtilis SMC head domain complexed with the cognate ScpA C-terminal domain"}}}