{"metadata":{"accession":"PF02604","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006442","hierarchy":null,"name":{"name":"Antitoxin Phd_YefM, type II toxin-antitoxin system","short":"PhdYeFM_antitox"},"description":[{"text":"<p>Members of this family act as antitoxins in type II toxin-antitoxin systems [[cite:PUB00015218]].  When bound to their toxin partners, they can bind DNA via the N-terminus and repress the expression of operons containing genes encoding the toxin and the antitoxin [[cite:PUB00054755]].  This domain complexes with Txe toxins containing [pfam:PF06769], Fic/DOC toxins containing [pfam:PF02661] and YafO toxins containing [pfam:PF13957].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00054755":{"PMID":20603017,"ISBN":null,"volume":"142","issue":"1","year":2010,"title":"Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.","URL":null,"raw_pages":"101-11","medline_journal":"Cell","ISO_journal":"Cell","authors":["Garcia-Pino A","Balasubramanian S","Wyns L","Gazit E","De Greve H","Magnuson RD","Charlier D","van Nuland NA","Loris R."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2010.05.039"},"PUB00015218":{"PMID":14659018,"ISBN":null,"volume":"4","issue":"12","year":2003,"title":"New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system.","URL":null,"raw_pages":"R81","medline_journal":"Genome Biol","ISO_journal":"Genome Biol.","authors":["Anantharaman V","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/gb-2003-4-12-r81"}},"set_info":{"accession":"CL0871","name":"YefM-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":33,"interactions":0,"matches":22715,"pathways":0,"proteins":22715,"proteomes":9546,"sets":1,"structural_models":{"alphafold":14574},"structures":24,"taxa":14306},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":12072},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8yzg","name":"Antitoxin protein from S. pneumoniae"}}}