{"metadata":{"accession":"PF02598","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003750","hierarchy":null,"name":{"name":"Putative RNA methyltransferase","short":"Methyltrn_RNA_3"},"description":[{"text":"<p>This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA [[cite:PUB00021971]], and may function as a methyltransferase [[cite:PUB00044735],[cite:PUB00057459]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044735":{"PMID":17338813,"ISBN":null,"volume":"8","issue":null,"year":2007,"title":"Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases.","URL":null,"raw_pages":"73","medline_journal":"BMC Bioinformatics","ISO_journal":"BMC Bioinformatics","authors":["Tkaczuk KL","Dunin-Horkawicz S","Purta E","Bujnicki JM."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2105-8-73"},"PUB00021971":{"PMID":12486711,"ISBN":null,"volume":"50","issue":"2","year":2003,"title":"Deep trefoil knot implicated in RNA binding found in an archaebacterial protein.","URL":null,"raw_pages":"177-83","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Zarembinski TI","Kim Y","Peterson K","Christendat D","Dharamsi A","Arrowsmith CH","Edwards AM","Joachimiak A."],"DOI_URL":"http://dx.doi.org/10.1002/prot.10311"},"PUB00057459":{"PMID":18844986,"ISBN":null,"volume":"9","issue":null,"year":2008,"title":"RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes.","URL":null,"raw_pages":"470","medline_journal":"BMC Genomics","ISO_journal":"BMC Genomics","authors":["Grosjean H","Gaspin C","Marck C","Decatur WA","de Crecy-Lagard V."],"DOI_URL":"http://dx.doi.org/10.1186/1471-2164-9-470"}},"set_info":{"accession":"CL0098","name":"SPOUT"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":71,"interactions":0,"matches":4061,"pathways":0,"proteins":3935,"proteomes":3194,"sets":1,"structural_models":{"alphafold":3423},"structures":5,"taxa":8305},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":140,"alignment:full":2978},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4rg1","name":"Methyltransferase domain of C9orf114"}}}