{"metadata":{"accession":"PF02597","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003749","hierarchy":null,"name":{"name":"ThiS family","short":"ThiS"},"description":[{"text":"<p>ThiS (thiaminS) is a 66 aa protein involved in sulphur transfer [swissprot:O32583]. ThiS is coded in the thiCEFSGH operon in E. coli. This family of proteins have two conserved Glycines at the COOH terminus. Thiocarboxylate is formed at the last G in the activation process. Sulphur is transferred from ThiI to ThiS in a reaction catalysed by IscS [[cite:PUB00007564]]. MoaD, [swissprot:P30748] a protein involved sulphur transfer in molybdopterin synthesis, is about the same length and shows limited sequence similarity to ThiS. Both have the conserved GG at the COOH end.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00007564":{"PMID":10781607,"ISBN":null,"volume":"275","issue":"26","year":2000,"title":"The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD.","URL":null,"raw_pages":"20096-103","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Lauhon CT","Kambampati R."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M002680200"}},"set_info":{"accession":"CL0072","name":"Ubiquitin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":112,"interactions":0,"matches":36990,"pathways":0,"proteins":36990,"proteomes":17893,"sets":1,"structural_models":{"alphafold":24446},"structures":39,"taxa":28116},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":145,"alignment:full":19044},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2cu3","name":"Crystal structure of TT1568 from Thermus thermophilus HB8"}}}