{"metadata":{"accession":"PF02594","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003746","hierarchy":null,"name":{"name":"PF1765 protein family","short":"PF1765-like"},"description":[{"text":"<p>This entry represents the homologues of UPF0235 protein PF1765 from from Pyrococcus furiosus. This proteins folds into a five-stranded curved mixed beta-sheet packed on one side with two alpha-helices [[cite:PUB00163221]]. PF1765 binds variably to dsDNA, ssDNA, and RNA, with a modest preference for single-stranded substrates [[cite:PUB00029013]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00163221":{"PMID":40916303,"ISBN":null,"volume":"782","issue":null,"year":2025,"title":"Crystal structure and nucleic acid binding activity of the conserved UPF0235 family protein PF1765 from Pyrococcus furiosus.","URL":null,"raw_pages":"152568","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem Biophys Res Commun","authors":["Yadav B","Gaikwad SS","Kumar A","Gupta GD","Kumar A","Makde RD."],"DOI_URL":"https://doi.org/10.1016/j.bbrc.2025.152568"},"PUB00029013":{"PMID":12975589,"ISBN":null,"volume":"27","issue":"3","year":2003,"title":"Resonance assignments for the hypothetical protein yggU from Escherichia coli.","URL":null,"raw_pages":"285-6","medline_journal":"J Biomol NMR","ISO_journal":"J. Biomol. NMR","authors":["Aramini JM","Mills JL","Xiao R","Acton TB","Wu MJ","Szyperski T","Montelione GT."],"DOI_URL":"http://dx.doi.org/10.1023/A:1025494323225"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":76,"interactions":0,"matches":8737,"pathways":0,"proteins":8737,"proteomes":7629,"sets":0,"structural_models":{"alphafold":6551},"structures":13,"taxa":14793},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":289,"alignment:full":5142},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9vyu","name":"Crystal structure of UPF0235 protein PF1765 from Pyrococcus furiosus crystallized with PEG1500 and glycerol at pH 8.0"}}}