This family catalyses the synthesis of thymidine monophosphate (dTMP) from deoxyuridine monophosphate (dUMP). The physiological co-substrate has not yet been identified. Previous designation of this family as being thymidylate synthase from one paper, [cite:PUB00075419], has been shown to be erroneous [[cite:PUB00057368]]. The proteins are uncharacterised.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00075419":{"PMID":10436953,"ISBN":null,"volume":"36","issue":"8","year":1997,"title":"[In situ hybridization for interleukin 4 and interleukin 5 messenger RNA in asthma].","URL":null,"raw_pages":"513-5","medline_journal":"Zhonghua Nei Ke Za Zhi","ISO_journal":"Zhonghua Nei Ke Za Zhi","authors":["Zhao R","Sun Y","Gao T."],"DOI_URL":null},"PUB00072924":{"PMID":11790254,"ISBN":null,"volume":"2","issue":"12","year":2001,"title":"Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences.","URL":null,"raw_pages":"RESEARCH0051","medline_journal":"Genome Biol","ISO_journal":"Genome Biol.","authors":["Iyer LM","Aravind L","Bork P","Hofmann K","Mushegian AR","Zhulin IB","Koonin EV."],"DOI_URL":"http://dx.doi.org/10.1186/gb-2001-2-12-research0051"},"PUB00057368":{"PMID":10426953,"ISBN":null,"volume":"6","issue":"8","year":1999,"title":"Identifying two ancient enzymes in Archaea using predicted secondary structure alignment.","URL":null,"raw_pages":"750-4","medline_journal":"Nat Struct Biol","ISO_journal":"Nat. Struct. Biol.","authors":["Xu H","Aurora R","Rose GD","White RH."],"DOI_URL":"http://dx.doi.org/10.1038/11525"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":268,"pathways":0,"proteins":267,"proteomes":149,"sets":1,"structural_models":{"alphafold":241},"structures":0,"taxa":354},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":77,"alignment:full":135},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}