{"metadata":{"accession":"PF02591","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003743","hierarchy":null,"name":{"name":"C4-type zinc ribbon domain","short":"Zn_ribbon_9"},"description":[{"text":"<p>Zn-ribbon_9 is a Zn-ribbon domain rich in aromatic and positively charged amino acid residues. This C-terminal Zn-ribbon domain consists of two beta-strands acting as a scaffold for the two Zn knuckles. Both pairs of cysteines making up the two Zn knuckles are situated at highly conserved sharp beta-turns, an arrangement that facilitates the tetrahedral coordination of the divalent Zn ion. The two Zn-knuckle cysteine motifs are separated by 20 residues, 9 of which form an alpha-helix (helix 4) [[cite:PUB00075417]].Structural modelling suggests this domain may bind nucleic acids [[cite:PUB00070793]]. The domain appears to bind flaA-mRNA, thus contributing to flagellum formation and motility [[cite:PUB00075417]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075417":{"PMID":20826163,"ISBN":null,"volume":"403","issue":"3","year":2010,"title":"The 2.2-A structure of the HP0958 protein from Helicobacter pylori reveals a kinked anti-parallel coiled-coil hairpin domain and a highly conserved ZN-ribbon domain.","URL":null,"raw_pages":"405-19","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Caly DL","O'Toole PW","Moore SA."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2010.08.051"},"PUB00070793":{"PMID":21348639,"ISBN":null,"volume":"15","issue":"7-8","year":2011,"title":"Ab initio modeling led annotation suggests nucleic acid binding function for many DUFs.","URL":null,"raw_pages":"431-8","medline_journal":"OMICS","ISO_journal":"OMICS","authors":["Rigden DJ."],"DOI_URL":"http://dx.doi.org/10.1089/omi.2010.0122"}},"set_info":{"accession":"CL0167","name":"Zn_Beta_Ribbon"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":6047,"pathways":0,"proteins":6047,"proteomes":6025,"sets":1,"structural_models":{"alphafold":3806},"structures":4,"taxa":8321},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":158,"alignment:full":3123},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}