{"metadata":{"accession":"PF02586","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003738","hierarchy":null,"name":{"name":"SOS response associated peptidase (SRAP)","short":"SRAP"},"description":[{"text":"<p>The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075418":{"PMID":23945014,"ISBN":null,"volume":"8","issue":null,"year":2013,"title":"Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems.","URL":null,"raw_pages":"20","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Aravind L","Anand S","Iyer LM."],"DOI_URL":"http://dx.doi.org/10.1186/1745-6150-8-20"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":96,"interactions":0,"matches":20441,"pathways":0,"proteins":20212,"proteomes":14674,"sets":0,"structural_models":{"alphafold":13289},"structures":19,"taxa":23969},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":345,"alignment:full":11099},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1zn6","name":"X-ray Crystal Structure of Protein Q7WLM8 from Bordetella bronchiseptica. Northeast Structural Genomics Consortium Target BoR19."}}}