{"metadata":{"accession":"PF02520","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003677","hierarchy":null,"name":{"name":"SXP/RAL-2 family protein Ani s 5-like, metal-binding domain","short":"ANIS5_cation-bd"},"description":[{"text":"<p>This domain is found in proteins from nematodes, including SXP/RAL-2 family protein Ani s 5 (ANIS5) from Anisakis simplex, and comprises two conserved motifs: SXP1 and SXP2 [[cite:PUB00097764]]. Although the function of this domain is not clear, structural information from ANIS5 revealed an alpha helical arrangement with a Calmodulin-like fold. Functional studies indicates that ANIS5 can bind magnesium and calcium, suggesting that this domain plays a role in cation binding [[cite:PUB00097763]]. These proteins are interesting targets to develop control strategies against the diseases caused by parasites.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097763":{"PMID":33371317,"ISBN":null,"volume":"21","issue":"24","year":2020,"title":"Identification and Physicochemical Characterization of a New Allergen from <i>Ascaris lumbricoides</i>.","URL":null,"raw_pages":null,"medline_journal":"Int J Mol Sci","ISO_journal":"Int J Mol Sci","authors":["Ahumada V","Manotas M","Zakzuk J","Aglas L","Coronado S","Briza P","Lackner P","Regino R","Araujo G","Ferreira F","Caraballo L."],"DOI_URL":null},"PUB00097764":{"PMID":24603892,"ISBN":null,"volume":"8","issue":"3","year":2014,"title":"Relationships between IgE/IgG4 epitopes, structure and function in Anisakis simplex Ani s 5, a member of the SXP/RAL-2 protein family.","URL":null,"raw_pages":"e2735","medline_journal":"PLoS Negl Trop Dis","ISO_journal":"PLoS Negl Trop Dis","authors":["Garcia-Mayoral MF","Trevino MA","Perez-Pinar T","Caballero ML","Knaute T","Umpierrez A","Bruix M","Rodriguez-Perez R."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":50,"interactions":0,"matches":2126,"pathways":0,"proteins":2048,"proteomes":94,"sets":0,"structural_models":{"alphafold":1927},"structures":1,"taxa":232},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":66,"alignment:full":1617},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}