{"metadata":{"accession":"PF02415","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003368","hierarchy":null,"name":{"name":"Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat","short":"Chlam_PMP"},"description":[{"text":"<p>This family contains several Chlamydia polymorphic membrane proteins. Chlamydia pneumoniae is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. Common for the Pmps are the tetrapeptide GGA(I/V/L) motif repeated several times in the N-terminal part. The C-terminal half is characterised by conserved tryptophans and a carboxy-terminal phenylalanine. A signal peptide leader sequence is predicted in 20 C. pneumoniae Pmps, which indicates an outer membrane localisation. Pmp10 and Pmp11 contain a signal peptidase II cleavage site suggesting lipid modification. The C. pneumoniae pmp genes represent 17.5% of the chlamydia-specific coding capacity and they are all transcribed during chlamydial growth but the function of Pmps remains unknown [[cite:PUB00015051]]. This family shows some similarity to [pfam:PF05594] and hence is likely to also form a beta-helical structure (personal obs:C Yeats).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00015051":{"PMID":11583841,"ISBN":null,"volume":"203","issue":"2","year":2001,"title":"Differential expression of Pmp10 in cell culture infected with Chlamydia pneumoniae CWL029.","URL":null,"raw_pages":"153-9","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol. Lett.","authors":["Pedersen AS","Christiansen G","Birkelund S."],"DOI_URL":"http://dx.doi.org/10.1111/j.1574-6968.2001.tb10834.x"}},"set_info":{"accession":"CL0268","name":"Pec_lyase-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":557,"interactions":0,"matches":5667,"pathways":0,"proteins":2631,"proteomes":838,"sets":1,"structural_models":{"alphafold":1511},"structures":0,"taxa":2170},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":524,"alignment:full":3378},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}