{"metadata":{"accession":"PF02410","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Ribosomal silencing factor during starvation","short":"RsfS"},"description":[{"text":"<p>This family is expressed by almost all bacterial and eukaryotic genomes but not by archaea. Its function is to down-regulate protein synthesis under conditions of nutrient shortage, and it does this by binding to protein L14 of the large ribosomal subunit, thus acting as a ribosomal silencing factor (RsfS) by blocking the joining of the ribosomal subunits [[cite:PUB00064845]]. This family is structurally homologous to nucleotidyltransferases.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00064845":{"PMID":22829778,"ISBN":null,"volume":"8","issue":"7","year":2012,"title":"RsfA (YbeB) proteins are conserved ribosomal silencing factors.","URL":null,"raw_pages":"e1002815","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet.","authors":["Hauser R","Pech M","Kijek J","Yamamoto H","Titz B","Naeve F","Tovchigrechko A","Yamamoto K","Szaflarski W","Takeuchi N","Stellberger T","Diefenbacher ME","Nierhaus KH","Uetz P."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pgen.1002815"}},"set_info":{"accession":"CL0260","name":"NTP_transf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":103,"interactions":0,"matches":21269,"pathways":0,"proteins":21229,"proteomes":20133,"sets":1,"structural_models":{"alphafold":14690},"structures":56,"taxa":31990},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":63,"alignment:full":11722},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3ups","name":"Crystal structure of iojap-like protein from Zymomonas mobilis"}}}