{"metadata":{"accession":"PF02006","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002855","hierarchy":null,"name":{"name":"Phosphopantothenate/pantothenate synthetase","short":"PPS_PS"},"description":[{"text":"<p>This family of archaeal proteins includes pantothenate synthetase from Methanosarcina mazei and 4-phosphopantoate--beta-alanine ligase (phosphopantothenate synthetase) from Pyrococcus kodakaraensis. Pantothenate synthetase catalyses the condensation of pantoate with beta-alanine in an ATP-dependent and ADP-producing reaction [[cite:PUB00066834]]. 4-phosphopantoate--beta-alanine ligase catalyses the conversion of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway. It cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase activity [[cite:PUB00060435]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00060435":{"PMID":19666462,"ISBN":null,"volume":"284","issue":"41","year":2009,"title":"Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea.","URL":null,"raw_pages":"28137-45","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Yokooji Y","Tomita H","Atomi H","Imanaka T."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M109.009696"},"PUB00066834":{"PMID":18422645,"ISBN":null,"volume":"275","issue":"11","year":2008,"title":"A novel isoform of pantothenate synthetase in the Archaea.","URL":null,"raw_pages":"2754-64","medline_journal":"FEBS J","ISO_journal":"FEBS J.","authors":["Ronconi S","Jonczyk R","Genschel U."],"DOI_URL":"http://dx.doi.org/10.1111/j.1742-4658.2008.06416.x"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":578,"pathways":0,"proteins":578,"proteomes":577,"sets":1,"structural_models":{"alphafold":541},"structures":5,"taxa":1045},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":65,"alignment:full":282},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4mb0","name":"Crystal structure of TON1374"}}}