{"metadata":{"accession":"PF01986","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002837","hierarchy":null,"name":{"name":"Domain of unknown function DUF123","short":"DUF123"},"description":[{"text":"<p>This archaebacterial domain has no known function. It is attached to an endonuclease domain in [swissprot:Q58030]. The domain contains several conserved cysteines and histidines. This suggests that the domain may be a zinc binding nucleic acid interaction domain (Bateman A unpubl.).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0418","name":"GIY-YIG"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":931,"pathways":0,"proteins":924,"proteomes":912,"sets":1,"structural_models":{"alphafold":790},"structures":0,"taxa":1943},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":46,"alignment:full":518},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}