{"metadata":{"accession":"PF01983","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002835","hierarchy":null,"name":{"name":"Guanylyl transferase CofC like","short":"CofC"},"description":[{"text":"<p>Coenzyme F420 is a hydride carrier cofactor that functions during methanogenesis.  This family of proteins represents CofC, a nucleotidyl transferase that is involved in coenzyme F420 biosynthesis.  CofC has been shown to catalyse the formation of lactyl-2-diphospho-5'-guanosine from 2-phospho-L-lactate and GTP [[cite:PUB00045885]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00045885":{"PMID":18260642,"ISBN":null,"volume":"47","issue":"9","year":2008,"title":"Identification and characterization of the 2-phospho-L-lactate guanylyltransferase involved in coenzyme F420 biosynthesis.","URL":null,"raw_pages":"3033-7","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Grochowski LL","Xu H","White RH."],"DOI_URL":"http://dx.doi.org/10.1021/bi702475t"}},"set_info":{"accession":"CL0110","name":"GT-A"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":3136,"pathways":0,"proteins":3120,"proteomes":3017,"sets":1,"structural_models":{"alphafold":1969},"structures":4,"taxa":4189},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":1539},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6bwg","name":"Crystal structure of native Rv2983 from Mycobacterium tuberculosis"}}}