{"metadata":{"accession":"PF01976","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002829","hierarchy":null,"name":{"name":"Protein of unknown function DUF116","short":"DUF116"},"description":[{"text":"<p>This archaebacterial protein has no known function. The protein contains seven conserved cysteines containing a CxxCxxC motif and may also be an integral membrane protein [[cite:PUB00096938]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00096938":{"PMID":25583072,"ISBN":null,"volume":"118","issue":null,"year":2015,"title":"Comparative genomic analysis of evolutionarily conserved but functionally uncharacterized membrane proteins in archaea: Prediction of novel components of secretion, membrane remodeling and glycosylation systems.","URL":null,"raw_pages":"302-12","medline_journal":"Biochimie","ISO_journal":"Biochimie","authors":["Makarova KS","Galperin MY","Koonin EV."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":983,"pathways":0,"proteins":974,"proteomes":868,"sets":0,"structural_models":{"alphafold":794},"structures":0,"taxa":1755},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":74,"alignment:full":590},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}