{"metadata":{"accession":"PF01973","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002826","hierarchy":null,"name":{"name":"6-hydroxymethylpterin diphosphokinase MptE-like","short":"MptE-like"},"description":[{"text":"<p>This domain can be found in a group of proteins, including archaeal 6-hydroxymethylpterin diphosphokinase (6-HMDPK), known as MptE, which catalyses the formation of 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) from 6-HMD and ATP [[cite:PUB00061602]]. 6-HMDP is the precursor of the pterin containing moiety of the essential C1-carriers tetrahydrofolate and tetrahydromethanopterin. This entry also includes a number of uncharacterised proteins from bacteria.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00061602":{"PMID":22931285,"ISBN":null,"volume":null,"issue":null,"year":2012,"title":"Comparative genomics guided discovery of two missing archaeal enzyme families involved in the biosynthesis of the pterin moiety of methanopterin and tetrahydrofolate.","URL":null,"raw_pages":null,"medline_journal":"ACS Chem Biol","ISO_journal":"ACS Chem. Biol.","authors":["De Crecy-Lagard V","Phillips G","Grochowski LL","El Yacoubi B","Jenney F","Adams MW","Murzin AG","White RH."],"DOI_URL":null}},"set_info":{"accession":"CL0948","name":"GT29-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":52,"interactions":0,"matches":3325,"pathways":0,"proteins":3321,"proteomes":2320,"sets":1,"structural_models":{"alphafold":2353},"structures":3,"taxa":4154},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":1733},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}