{"metadata":{"accession":"PF01970","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002823","hierarchy":null,"name":{"name":"Tripartite tricarboxylate transporter TctA family","short":"TctA"},"description":[{"text":"<p>This family, formerly known as DUF112, is a family of bacterial and archaeal tripartite tricarboxylate transporters of the extracytoplasmic solute binding receptor-dependent transporter group of families, distinct from the ABC and TRAP-T families [[cite:PUB00106923]]. TctA is part of the tripartite TctABC system which, as characterised in S. typhimurium [[cite:PUB00106922]], is a secondary carrier that depends for activity on the extracytoplasmic tricarboxylate-binding receptor TctC as well as two integral membrane proteins, TctA and TctB. complete three-component systems are found only in bacteria. TctA is a large transmembrane protein with up to 12 predicted membrane spanning regions in bacteria and up to 11 such in archaea, with the N-terminal within the cytoplasm. TctA is thought to be a permease, and in most other bacteria functions without TctB and TctC molecules [[cite:PUB00106923]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00106922":{"PMID":6141166,"ISBN":null,"volume":"259","issue":"3","year":1984,"title":"Tricarboxylate-binding proteins of Salmonella typhimurium. Purification, crystallization, and physical properties.","URL":null,"raw_pages":"1586-92","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Sweet GD","Kay CM","Kay WW."],"DOI_URL":null},"PUB00106923":{"PMID":14499931,"ISBN":null,"volume":"154","issue":"7","year":2003,"title":"The tripartite tricarboxylate transporter (TTT) family.","URL":null,"raw_pages":"457-65","medline_journal":"Res Microbiol","ISO_journal":"Res Microbiol","authors":["Winnen B","Hvorup RN","Saier MH Jr."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":18244,"pathways":0,"proteins":18234,"proteomes":7121,"sets":0,"structural_models":{"alphafold":11882},"structures":0,"taxa":9990},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":285,"alignment:full":9594},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}