{"metadata":{"accession":"PF01959","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR030960","hierarchy":null,"name":{"name":"3-dehydroquinate synthase II N-terminal domain","short":"DHQS"},"description":[{"text":"<p>This entry represents the N-terminal TIM barrel domain of 3-dehydroquinate synthase II. This family includes members of 3-dehydroquinate synthase II ([ec:1.4.1.24]), encoded by aroB genes in M. maripaludis which is widely distributed in methanogens. In M. jannaschii, proteins ADTH synthase (AroA) and DHQ synthase II (AroB) are required to convert 6-deoxy-5-ketofructose-1-phosphate (DKFP) and aspartate semialdehyde to 3-dehydroquinate (DHQ) in vitro [[cite:PUB00109170],[cite:PUB00060486]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"3-dehydroquinate_synthase_II","extract":"<p><b>3-dehydroquinate synthase II</b> (EC <span class=\"external text\">1.4.1.24</span>, <i>DHQ synthase II</i>, <i>MJ1249 (gene)</i>, <i>aroB' (gene)</i>) is an enzyme with systematic name <i>2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD<sup>+</sup> oxidoreductase (deaminating)</i>. This enzyme catalyses the following chemical reaction</p>","thumbnail":null}],"literature":{"PUB00060486":{"PMID":15182204,"ISBN":null,"volume":"43","issue":"23","year":2004,"title":"L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the precursors to the aromatic amino acids in Methanocaldococcus jannaschii.","URL":null,"raw_pages":"7618-27","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["White RH."],"DOI_URL":"http://dx.doi.org/10.1021/bi0495127"},"PUB00109170":{"PMID":17010158,"ISBN":null,"volume":"62","issue":"4","year":2006,"title":"Biochemical and genetic characterization of an early step in a novel pathway for the biosynthesis of aromatic amino acids and p-aminobenzoic acid in the archaeon Methanococcus maripaludis.","URL":null,"raw_pages":"1117-31","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Porat I","Sieprawska-Lupa M","Teng Q","Bohanon FJ","White RH","Whitman WB."],"DOI_URL":null}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":24,"interactions":0,"matches":1855,"pathways":0,"proteins":1847,"proteomes":1461,"sets":1,"structural_models":{"alphafold":1397},"structures":0,"taxa":2975},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":64,"alignment:full":1010},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}