{"metadata":{"accession":"PF01956","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002809","hierarchy":null,"name":{"name":"Integral membrane protein EMC3/TMCO1-like","short":"EMC3_TMCO1"},"description":[{"text":"<p>This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding [[cite:PUB00061987]], and TMCO1, a ER calcium load-activated calcium channel [[cite:PUB00081416]]. Archaeal members may function as insertases of the archaeal plasma membrane [[cite:PUB00086930]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00081416":{"PMID":27212239,"ISBN":null,"volume":"165","issue":"6","year":2016,"title":"TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel.","URL":null,"raw_pages":"1454-66","medline_journal":"Cell","ISO_journal":"Cell","authors":["Wang QC","Zheng Q","Tan H","Zhang B","Li X","Yang Y","Yu J","Liu Y","Chai H","Wang X","Sun Z","Wang JQ","Zhu S","Wang F","Yang M","Guo C","Wang H","Zheng Q","Li Y","Chen Q","Zhou A","Tang TS."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2016.04.051"},"PUB00061987":{"PMID":19325107,"ISBN":null,"volume":"323","issue":"5922","year":2009,"title":"Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.","URL":null,"raw_pages":"1693-7","medline_journal":"Science","ISO_journal":"Science","authors":["Jonikas MC","Collins SR","Denic V","Oh E","Quan EM","Schmid V","Weibezahn J","Schwappach B","Walter P","Weissman JS","Schuldiner M."],"DOI_URL":"http://dx.doi.org/10.1126/science.1167983"},"PUB00086930":{"PMID":26256539,"ISBN":null,"volume":"23","issue":"9","year":2015,"title":"A YidC-like Protein in the Archaeal Plasma Membrane.","URL":null,"raw_pages":"1715-24","medline_journal":"Structure","ISO_journal":"Structure","authors":["Borowska MT","Dominik PK","Anghel SA","Kossiakoff AA","Keenan RJ."],"DOI_URL":"https://doi.org/10.1016/j.str.2015.06.025"}},"set_info":{"accession":"CL0376","name":"Oxa1"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":89,"interactions":0,"matches":7342,"pathways":0,"proteins":7263,"proteomes":3937,"sets":1,"structural_models":{"alphafold":6324},"structures":16,"taxa":9997},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":51,"alignment:full":5337},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}