{"metadata":{"accession":"PF01955","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002808","hierarchy":null,"name":{"name":"Adenosylcobinamide amidohydrolase","short":"CbiZ"},"description":[{"text":"<p>This prokaryotic protein family includes CbiZ which converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route [[cite:PUB00019258]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Cobalamin_biosynthesis","extract":"<p><b>Cobalamin biosynthesis</b> is the process by which bacteria and archea make cobalamin, vitamin B<sub>12</sub>. Many steps are involved in converting aminolevulinic acid via uroporphyrinogen III and adenosylcobyric acid to the final forms in which it is used by enzymes in both the producing organisms and other species, including humans who acquire it through their diet.</p>","thumbnail":null}],"literature":{"PUB00019258":{"PMID":14990804,"ISBN":null,"volume":"101","issue":"10","year":2004,"title":"CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea.","URL":null,"raw_pages":"3591-6","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Woodson JD","Escalante-Semerena JC."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0305939101"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":14,"interactions":0,"matches":2701,"pathways":0,"proteins":2665,"proteomes":2525,"sets":0,"structural_models":{"alphafold":1772},"structures":0,"taxa":3886},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":64,"alignment:full":1345},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}