{"metadata":{"accession":"PF01954","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR008203","hierarchy":null,"name":{"name":"AF2212-like","short":"AF2212-like"},"description":[{"text":"<p>This family includes short bacterial and archaebacterial proteins thought to be antitoxin components of the a type II toxin-antitoxin (TA) system. This entry includes AF2212 from Archaeoglobus fulgidus which has sequence similarity with the AbrB superfamily of DNA-binding proteins, identified as antitoxins [[cite:PUB00056596],[cite:PUB00056164]]. The secondary structure of AF2212 revealed at least three beta-strands that are most conserved in other AbrB superfamily members [[cite:PUB00056164]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00056164":{"PMID":19493340,"ISBN":null,"volume":"4","issue":null,"year":2009,"title":"Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes.","URL":null,"raw_pages":"19","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Makarova KS","Wolf YI","Koonin EV."],"DOI_URL":"http://dx.doi.org/10.1186/1745-6150-4-29"},"PUB00056596":{"PMID":15718296,"ISBN":null,"volume":"33","issue":"3","year":2005,"title":"Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.","URL":null,"raw_pages":"966-76","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Pandey DP","Gerdes K."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gki201"}},"set_info":{"accession":"CL0866","name":"ALR_C-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":440,"pathways":0,"proteins":440,"proteomes":202,"sets":1,"structural_models":{"alphafold":371},"structures":1,"taxa":642},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":41,"alignment:full":265},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}