{"metadata":{"accession":"PF01951","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR023572","hierarchy":null,"name":{"name":"Archease protein family (MTH1598/TM1083)","short":"Archease"},"description":[{"text":"<p>This archease family of proteins [[cite:PUB00109176]], has two SHS2 domains [[cite:PUB00057445]], with one inserted into another. It is predicted to be an enzyme [[cite:PUB00057445]]. It is predicted to act as a chaperone in DNA/RNA metabolism [[cite:PUB00109176]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Archease","extract":"<p>In molecular biology, the <b>archease</b>s are a conserved superfamily of proteins represented in all three domains of life. Archeases are typically small proteins, 16-20 kDa in size. Archease genes are generally located adjacent to genes encoding proteins involved in DNA or RNA processing and have therefore been predicted to be modulators or chaperones involved in DNA or RNA metabolism. Many of the roles of archeases remain to be established experimentally.</p>","thumbnail":null}],"literature":{"PUB00045441":{"PMID":17470432,"ISBN":null,"volume":"282","issue":"26","year":2007,"title":"Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase.","URL":null,"raw_pages":"18711-21","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Auxilien S","El Khadali F","Rasmussen A","Douthwaite S","Grosjean H."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M607459200"},"PUB00057445":{"PMID":15281131,"ISBN":null,"volume":"56","issue":"4","year":2004,"title":"The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies.","URL":null,"raw_pages":"795-807","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Anantharaman V","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1002/prot.20140"},"PUB00109176":{"PMID":15162483,"ISBN":null,"volume":"56","issue":"1","year":2004,"title":"Predicted role for the archease protein family based on structural and sequence analysis of TM1083 and MTH1598, two proteins structurally characterized through structural genomics efforts.","URL":null,"raw_pages":"19-27","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Canaves JM."],"DOI_URL":null}},"set_info":{"accession":"CL0319","name":"SHS2"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":34,"interactions":0,"matches":3542,"pathways":0,"proteins":3523,"proteomes":2944,"sets":1,"structural_models":{"alphafold":2910},"structures":9,"taxa":7482},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":172,"alignment:full":2300},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4n2p","name":"Structure of Archease from Pyrococcus horikoshii"}}}