{"metadata":{"accession":"PF01950","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002803","hierarchy":null,"name":{"name":"Fructose-1,6-bisphosphatase","short":"FBPase_3"},"description":[{"text":"<p>This is a family of bacterial and archaeal fructose-1,6-bisphosphatases (FBPases).  FBPase catalyses the hydrolysis of D-fructose-1,6-bisphosphate (FBP) to D-fructose-6-phosphate (F6P) and orthophosphate and is an essential regulatory enzyme in the glyconeogenic pathway.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Fructose_1,6-bisphosphatase","extract":"<p>The enzyme <b>fructose bisphosphatase</b> catalyses the conversion of fructose-1,6-bisphosphate to fructose 6-phosphate in gluconeogenesis and the Calvin cycle, which are both anabolic pathways:</p>","thumbnail":null}],"literature":{"PUB00020986":{"PMID":15274916,"ISBN":null,"volume":"12","issue":"6","year":2004,"title":"The first crystal structure of the novel class of fructose-1,6-bisphosphatase present in thermophilic archaea.","URL":null,"raw_pages":"949-59","medline_journal":"Structure","ISO_journal":"Structure","authors":["Nishimasu H","Fushinobu S","Shoun H","Wakagi T."],"DOI_URL":"http://dx.doi.org/10.1016/j.str.2004.03.026"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":518,"pathways":0,"proteins":507,"proteomes":487,"sets":0,"structural_models":{"alphafold":440},"structures":8,"taxa":1110},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":49,"alignment:full":281},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1umg","name":"Crystal structure of fructose-1,6-bisphosphatase"}}}