{"metadata":{"accession":"PF01949","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002802","hierarchy":null,"name":{"name":"Endonuclease dU","short":"Endo_dU"},"description":[{"text":"<p>This family includes Endonuclease dU from Archaeoglobus fulgidus (Endo_dU, AF_1433) and similar proteins mainly found in archaea. Sequence and structure analysis to identify RNase H-like superfamily members, has clustered this family in endonuclease Clade V, thus suggesting endonuclease activity of these proteins [[cite:PUB00098031]]. Endo_dU, which cleave the 3'-side of deoxyuridine (dU) on DNA substrates, shows a typical RNase H-like fold, with a core structure of five beta-strands and three alpha-helices. It may participate in DNA repair [[cite:PUB00160071]]. This family was formerly known as DUF99.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00160071":{"PMID":39426726,"ISBN":null,"volume":"300","issue":"11","year":2024,"title":"DUF99 family proteins are novel endonucleases that cleave deoxyuridine on DNA substrates.","URL":null,"raw_pages":"107901","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Li J","Xia R","Huang WC","Gu J","Li M."],"DOI_URL":"https://doi.org/10.1016/j.jbc.2024.107901"},"PUB00098031":{"PMID":24464998,"ISBN":null,"volume":"42","issue":"7","year":2014,"title":"The RNase H-like superfamily: new members, comparative structural analysis and evolutionary classification.","URL":null,"raw_pages":"4160-79","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Majorek KA","Dunin-Horkawicz S","Steczkiewicz K","Muszewska A","Nowotny M","Ginalski K","Bujnicki JM."],"DOI_URL":null}},"set_info":{"accession":"CL0219","name":"RNase_H"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":778,"pathways":0,"proteins":778,"proteomes":762,"sets":1,"structural_models":{"alphafold":660},"structures":1,"taxa":1518},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":77,"alignment:full":373},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2qh9","name":"The crystal structure of a protein of unknown function from Archaeoglobus fulgidus DSM 4304"}}}