{"metadata":{"accession":"PF01947","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002800","hierarchy":null,"name":{"name":"Chorismate pyruvate-lyase Rv2949c-like","short":"Rv2949c-like"},"description":[{"text":"<p>This domain is found in chorismate pyruvate-lyases ([ec:4.1.3.40], also known as 4-HB synthase and p-hydroxybenzoic acid synthase) such as those found in Mycobacterium tuberculosis where it removes the pyruvyl group from chorismate to provide 4-hydroxybenzoate (4HB) [[cite:PUB00086017]]. The chorismate pyruvate-lyase encoded by sll1797 in cyanobacteria Synechocystis sp. , has been shown to catalyse the initial and essential step in plastoquinone biosynthesis [[cite:PUB00097745]]. In E. coli, the chorismate lyase (UbiC) catalyses the conversion of chorismate to p-hydroxybenzoate and pyruvate in the biosynthesis of ubiquinone as well [[cite:PUB00097746]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097745":{"PMID":24337576,"ISBN":null,"volume":"289","issue":"5","year":2014,"title":"Chorismate pyruvate-lyase and 4-hydroxy-3-solanesylbenzoate decarboxylase are required for plastoquinone biosynthesis in the cyanobacterium Synechocystis sp. PCC6803.","URL":null,"raw_pages":"2675-86","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Pfaff C","Glindemann N","Gruber J","Frentzen M","Sadre R."],"DOI_URL":null},"PUB00086017":{"PMID":16210318,"ISBN":null,"volume":"280","issue":"49","year":2005,"title":"p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis.","URL":null,"raw_pages":"40699-706","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Stadthagen G","Kordulakova J","Griffin R","Constant P","Bottova I","Barilone N","Gicquel B","Daffe M","Jackson M."],"DOI_URL":"https://doi.org/10.1074/jbc.M508332200"},"PUB00097746":{"PMID":20437231,"ISBN":null,"volume":"87","issue":"4","year":2010,"title":"Functional analysis of genes for benzoate metabolism in the albicidin biosynthetic region of Xanthomonas albilineans.","URL":null,"raw_pages":"1475-85","medline_journal":"Appl Microbiol Biotechnol","ISO_journal":"Appl Microbiol Biotechnol","authors":["Hashimi SM","Birch RG."],"DOI_URL":null}},"set_info":{"accession":"CL0122","name":"UTRA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":741,"pathways":0,"proteins":726,"proteomes":660,"sets":1,"structural_models":{"alphafold":531},"structures":1,"taxa":1609},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":20,"alignment:full":505},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}