{"metadata":{"accession":"PF01937","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002791","hierarchy":null,"name":{"name":"Damage-control phosphatase ARMT1-like domain","short":"ARMT1-like_dom"},"description":[{"text":"<p>This domain is widely distributed in all domains of life and occur in stand-alone form and as C-terminal fusions to pantothenate kinase (PanK) in plants and animals. They are metal-dependent phosphatases involved in metabolic damage-control processes termed \"damage pre-emption\" or \"housecleaning\". S.cerevisiae Damage-control phosphatase YMR027W and the human orthologue Damage-control phosphatase ARMT1 (also known as C6orf211) are involved in response to DNA damage, a damage pre-emption function. Crystal structure of Damage-control phosphatase At2g17340 from Arabidopsis revealed a novel protein fold and several conserved residues coordinating a metal ion (probably Mg2+), which exhibits a high degree of conservation, suggesting that the metal-binding site is central for the function [[cite:PUB00088733]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00088733":{"PMID":27322068,"ISBN":null,"volume":"12","issue":"8","year":2016,"title":"A family of metal-dependent phosphatases implicated in metabolite damage-control.","URL":null,"raw_pages":"621-7","medline_journal":"Nat Chem Biol","ISO_journal":"Nat. Chem. Biol.","authors":["Huang L","Khusnutdinova A","Nocek B","Brown G","Xu X","Cui H","Petit P","Flick R","Zallot R","Balmant K","Ziemak MJ","Shanklin J","de Crecy-Lagard V","Fiehn O","Gregory JF 3rd","Joachimiak A","Savchenko A","Yakunin AF","Hanson AD."],"DOI_URL":"https://doi.org/10.1038/nchembio.2108"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":110,"interactions":0,"matches":9512,"pathways":0,"proteins":9217,"proteomes":4951,"sets":0,"structural_models":{"alphafold":7564},"structures":16,"taxa":11762},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":78,"alignment:full":6884},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6umq","name":"Structure of DUF89"}}}