{"metadata":{"accession":"PF01933","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002882","hierarchy":null,"name":{"name":"2-phospho-L-lactate transferase CofD","short":"CofD"},"description":[{"text":"<p>This entry contains 2-phospho-L-lactate transferase (CofD), phosphoenolpyruvate transferase and related sequences. CofD catalyses the fourth step in the biosynthesis of coenzyme F420, which is the transfer of the 2-phospholactate moiety from lactyl (2)diphospho-(5') guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of the L-lactyl phosphodiester of 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (F420-0) and GMP. F420 is a flavin derivative found in methanogens, Mycobacteria, and several other lineages. This enzyme is characterised so far in Methanocaldococcus jannaschii (Methanococcus jannaschii) [[cite:PUB00013496]] but appears restricted to F420-containing species and is predicted to carry out the same function in these other species. CofD monomer contains 12 beta- strands, seven of them form a Rossmann fold, and 13 alpha-helices [[cite:PUB00050875]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00050875":{"PMID":18252724,"ISBN":null,"volume":"283","issue":"17","year":2008,"title":"Molecular insights into the biosynthesis of the F420 coenzyme.","URL":null,"raw_pages":"11832-40","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Forouhar F","Abashidze M","Xu H","Grochowski LL","Seetharaman J","Hussain M","Kuzin A","Chen Y","Zhou W","Xiao R","Acton TB","Montelione GT","Galinier A","White RH","Tong L."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M710352200"},"PUB00013496":{"PMID":11888293,"ISBN":null,"volume":"41","issue":"11","year":2002,"title":"Characterization of the 2-phospho-L-lactate transferase enzyme involved in coenzyme F(420) biosynthesis in Methanococcus jannaschii.","URL":null,"raw_pages":"3754-61","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Graupner M","Xu H","White RH."],"DOI_URL":"http://dx.doi.org/10.1021/bi011937v"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":45,"interactions":0,"matches":14214,"pathways":0,"proteins":14174,"proteomes":10830,"sets":0,"structural_models":{"alphafold":9318},"structures":13,"taxa":17069},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":170,"alignment:full":7615},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2q7x","name":"Crystal structure of a putative phospho transferase (sp_1565) from streptococcus pneumoniae tigr4 at 2.00 A resolution"}}}