{"metadata":{"accession":"PF01909","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002934","hierarchy":null,"name":{"name":"Nucleotidyltransferase domain","short":"NTP_transf_2"},"description":[{"text":"<p>Members of this family belong to a large family of nucleotidyltransferases [[cite:PUB00005745]]. This family includes kanamycin nucleotidyltransferase (KNTase) which is a plasmid-coded enzyme responsible for some types of bacterial resistance to aminoglycosides. KNTase in-activates antibiotics by catalysing the addition of a nucleotidyl group onto the drug.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00005745":{"PMID":7482698,"ISBN":null,"volume":"20","issue":"9","year":1995,"title":"DNA polymerase beta belongs to an ancient nucleotidyltransferase superfamily.","URL":null,"raw_pages":"345-7","medline_journal":"Trends Biochem Sci","ISO_journal":"Trends Biochem. Sci.","authors":["Holm L","Sander C."],"DOI_URL":"http://dx.doi.org/10.1016/S0968-0004(00)89071-4"}},"set_info":{"accession":"CL0260","name":"NTP_transf"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":272,"interactions":0,"matches":24705,"pathways":0,"proteins":24660,"proteomes":12011,"sets":1,"structural_models":{"alphafold":16552},"structures":133,"taxa":19472},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":64,"alignment:full":12885},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1no5","name":"Structure of HI0073 from Haemophilus influenzae, the nucleotide binding domain of the HI0073/HI0074 two protein nucleotidyl transferase."}}}