{"metadata":{"accession":"PF01895","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR026022","hierarchy":null,"name":{"name":"PhoU domain","short":"PhoU"},"description":[{"text":"<p>This family contains phosphate regulatory proteins including PhoU. PhoU proteins are known to play a role in the regulation of phosphate uptake. The PhoU domain is composed of a three helix bundle [[cite:PUB00031207]]. The PhoU protein contains two copies of this domain. The domain binds to an iron cluster via its conserved E/DXXXD motif.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00031207":{"PMID":15716271,"ISBN":null,"volume":"280","issue":"16","year":2005,"title":"Crystal structure of a PhoU protein homologue: a new class of metalloprotein containing multinuclear iron clusters.","URL":null,"raw_pages":"15960-6","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Liu J","Lou Y","Yokota H","Adams PD","Kim R","Kim SH."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M414117200"}},"set_info":{"accession":"CL0297","name":"PhoU"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":45912,"pathways":0,"proteins":24850,"proteomes":15876,"sets":1,"structural_models":{"alphafold":16970},"structures":10,"taxa":22728},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":198,"alignment:full":23712},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1sum","name":"Crystal structure of a hypothetical protein at 2.0 A resolution"}}}