{"metadata":{"accession":"PF01887","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR046469","hierarchy":null,"name":{"name":"SAM hydroxide adenosyltransferase N-terminal domain","short":"SAM_HAT_N"},"description":[{"text":"<p>This is a family of proteins, previously known as DUF62, found in archaebacteria and bacteria. The structure of proteins in this family is similar to that of a bacterial fluorinating enzyme [[cite:PUB00047427]]. S-adenosyl-l-methionine hydroxide adenosyltransferases utilises a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion [[cite:PUB00054078]]. This family used to be known as DUF62.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00054078":{"PMID":18675376,"ISBN":null,"volume":"12","issue":"5","year":2008,"title":"The fluorinase, the chlorinase and the duf-62 enzymes.","URL":null,"raw_pages":"582-92","medline_journal":"Curr Opin Chem Biol","ISO_journal":"Curr Opin Chem Biol","authors":["Deng H","O'Hagan D."],"DOI_URL":"http://dx.doi.org/10.1016/j.cbpa.2008.06.036"},"PUB00047427":{"PMID":17910070,"ISBN":null,"volume":"70","issue":"2","year":2008,"title":"Crystal structure of a conserved protein of unknown function (MJ1651) from Methanococcus jannaschii.","URL":null,"raw_pages":"572-7","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Rao KN","Burley SK","Swaminathan S."],"DOI_URL":"http://dx.doi.org/10.1002/prot.21646"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":4632,"pathways":0,"proteins":4611,"proteomes":4378,"sets":0,"structural_models":{"alphafold":3211},"structures":33,"taxa":7070},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":238,"alignment:full":2337},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2cw5","name":"Crystal structure of a conserved hypothetical protein from Thermus thermophilus HB8"}}}