{"metadata":{"accession":"PF01886","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002746","hierarchy":null,"name":{"name":"Protein of unknown function DUF61","short":"DUF61"},"description":[{"text":"<p>This Domain of unknown function 61 (DUF61) family of proteins are widely distributed in archaea. In crenarchaea, the genes of DUF61 proteins are in an operon containing two genes of box C/D RNA protein complexes. The NMR structure of a DUF61 family member from the hyperthermophilic archaeon Sulfolobus solfataricus revealed a rigid core structure and flexible N- and C-terminal regions, including a negatively-charged independent C-terminal helix. The core structure consists of N- and C-terminal subdomains, in which the C-terminal subdomain shows significant structural similarity with several nucleic acid binding proteins [[cite:PUB00098020]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098020":{"PMID":29526782,"ISBN":null,"volume":"203","issue":"2","year":2018,"title":"Solution structure of an archaeal DUF61 family protein SSO0941 encoded by a gene in the operon of box C/D RNA protein complexes.","URL":null,"raw_pages":"179-184","medline_journal":"J Struct Biol","ISO_journal":"J Struct Biol","authors":["Zhou T","Yao X","Wang J","Feng Y."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":196,"pathways":0,"proteins":196,"proteomes":193,"sets":0,"structural_models":{"alphafold":181},"structures":1,"taxa":381},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":71,"alignment:full":100},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}