{"metadata":{"accession":"PF01867","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002729","hierarchy":null,"name":{"name":"CRISPR associated protein Cas1","short":"Cas_Cas1"},"description":[{"text":"<p>Clustered regularly interspaced short palindromic repeats (CRISPRs) are a family of DNA direct repeats found in many prokaryotic genomes. This family of proteins corresponds to Cas1, a CRISPR-associated protein.  Cas1 may be involved in linking DNA segments to CRISPR [[cite:PUB00043290]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Cas1","extract":"<p><b>CRISPR-associated protein 1 (cas1)</b> is one of the two universally conserved proteins found in the CRISPR prokaryotic immune defense system. Cas1 is a metal-dependent DNA-specific endonuclease that produces double-stranded DNA fragments. Cas1 forms a stable complex with the other universally conserved CRISPR-associated protein, cas2, which is essential to spacer acquisition for CRISPR systems.</p>","thumbnail":null}],"literature":{"PUB00020781":{"PMID":16292354,"ISBN":null,"volume":"1","issue":"6","year":2005,"title":"A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.","URL":null,"raw_pages":"e60","medline_journal":"PLoS Comput Biol","ISO_journal":"PLoS Comput. Biol.","authors":["Haft DH","Selengut J","Mongodin EF","Nelson KE."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pcbi.0010060"},"PUB00043290":{"PMID":16079334,"ISBN":null,"volume":"151","issue":"Pt 8","year":2005,"title":"Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin.","URL":null,"raw_pages":"2551-61","medline_journal":"Microbiology","ISO_journal":"Microbiology (Reading, Engl.)","authors":["Bolotin A","Quinquis B","Sorokin A","Ehrlich SD."],"DOI_URL":"http://dx.doi.org/10.1099/mic.0.28048-0"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":20,"interactions":0,"matches":9654,"pathways":0,"proteins":8983,"proteomes":6519,"sets":0,"structural_models":{"alphafold":6264},"structures":74,"taxa":11546},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":261,"alignment:full":5591},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2yzs","name":"Crystal structure of uncharacterized conserved protein from Aquifex aeolicus"}}}