{"metadata":{"accession":"PF01732","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022382","hierarchy":null,"name":{"name":"Mycoplasma immunoglobulin protease","short":"Myco_protease"},"description":[{"text":"<p>This is the serine protease domain of MIP (Mycoplasma immunoglobulin protease), a protein that is related to pathogenicity of animal and human pathogenic Mycoplasmas [[cite:PUB00098027],[cite:PUB00098028],[cite:PUB00098029],[cite:PUB00151017]]. This protein functions together with the Ig binding protein M (MIB) to evade host Ig-mediated defense against the MIB-MIP system, which is a novel mechanism that protects mycoplasma against host immune response [[cite:PUB00098028],[cite:PUB00151017]]. MIB tightly interacts to the antigen-binding fragment (Fab) and recruits the MIP protease that is activated and cleaves the IgG heavy chain, disrupting the antigen binding site. Therefore, the MIB-MIP system appears to be crucial to mycoplasma immune evasion [[cite:PUB00151017]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151017":{"PMID":33674316,"ISBN":null,"volume":"7","issue":"10","year":2021,"title":"The mycoplasma surface proteins MIB and MIP promote the dissociation of the antibody-antigen interaction. ","URL":null,"raw_pages":"eabf2403","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Nottelet P","Bataille L","Gourgues G","Anger R","Lartigue C","Sirand-Pugnet P","Marza E","Fronzes R","Arfi Y."],"DOI_URL":null},"PUB00098027":{"PMID":32373096,"ISBN":null,"volume":"11","issue":null,"year":2020,"title":"Characterization of an Immunoglobulin Binding Protein (IbpM) From Mycoplasma pneumoniae.","URL":null,"raw_pages":"685","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Blotz C","Singh N","Dumke R","Stulke J."],"DOI_URL":null},"PUB00098028":{"PMID":31497004,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"Subversion of the Immune Response by Human Pathogenic Mycoplasmas.","URL":null,"raw_pages":"1934","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Qin L","Chen Y","You X."],"DOI_URL":null},"PUB00098029":{"PMID":31540994,"ISBN":null,"volume":"85","issue":"23","year":2019,"title":"Proteases as Secreted Exoproteins in Mycoplasmas from Ruminant Lungs and Their Impact on Surface-Exposed Proteins.","URL":null,"raw_pages":null,"medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["Ganter S","Miotello G","Manso-Silvan L","Armengaud J","Tardy F","Gaurivaud P","Thiaucourt F."],"DOI_URL":null}},"set_info":{"accession":"CL0124","name":"Peptidase_PA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":483,"pathways":0,"proteins":480,"proteomes":120,"sets":1,"structural_models":{"alphafold":346},"structures":1,"taxa":185},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":298},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}