{"metadata":{"accession":"PF01709","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048300","hierarchy":null,"name":{"name":"TACO1/YebC second and third domain","short":"Transcrip_reg"},"description":[{"text":"<p>This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1 [[cite:PUB00057436]]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [[cite:PUB00057437]]. This entry represents the second and third domains in this protein, with one domain nested within the other.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00057436":{"PMID":19503089,"ISBN":null,"volume":"41","issue":"7","year":2009,"title":"Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome.","URL":null,"raw_pages":"833-7","medline_journal":"Nat Genet","ISO_journal":"Nat. Genet.","authors":["Weraarpachai W","Antonicka H","Sasarman F","Seeger J","Schrank B","Kolesar JE","Lochmuller H","Chevrette M","Kaufman BA","Horvath R","Shoubridge EA."],"DOI_URL":"http://dx.doi.org/10.1038/ng.390"},"PUB00057437":{"PMID":18641136,"ISBN":null,"volume":"190","issue":"18","year":2008,"title":"The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production.","URL":null,"raw_pages":"6217-27","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Liang H","Li L","Dong Z","Surette MG","Duan K."],"DOI_URL":"http://dx.doi.org/10.1128/JB.00428-08"},"PUB00027019":{"PMID":12060744,"ISBN":null,"volume":"99","issue":"12","year":2002,"title":"Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus.","URL":null,"raw_pages":"7980-5","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Shin DH","Yokota H","Kim R","Kim SH."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.132241399"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":67,"interactions":0,"matches":23105,"pathways":0,"proteins":23092,"proteomes":20420,"sets":0,"structural_models":{"alphafold":15841},"structures":12,"taxa":32390},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":569,"alignment:full":12179},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1mw7","name":"X-RAY STRUCTURE OF Y162_HELPY NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET PR6"}}}