{"metadata":{"accession":"PF01594","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002549","hierarchy":null,"name":{"name":"AI-2E family transporter","short":"AI-2E_transport"},"description":[{"text":"<p>This family includes four different proteins from E. coli alone. One of them, YdgG or TqsA, has been shown to mediate transport of the quorum-sensing signal autoinducer 2 (AI-2). It is not clear if TqsA enhances secretion of AI-2 or inhibits AI-2 uptake. By altering the intracellular concentration of AI-2, TqsA affects gene expression in biofilms and biofilm formation [[cite:PUB00076990]]. TsqA belongs to the AI-2 exporter (AI-2E) superfamily [[cite:PUB00076989]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076990":{"PMID":16385049,"ISBN":null,"volume":"188","issue":"2","year":2006,"title":"YdgG (TqsA) controls biofilm formation in Escherichia coli K-12 through autoinducer 2 transport.","URL":null,"raw_pages":"587-98","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Herzberg M","Kaye IK","Peti W","Wood TK."],"DOI_URL":"http://dx.doi.org/10.1128/JB.188.2.587-598.2006"},"PUB00076989":{"PMID":20559013,"ISBN":null,"volume":"18","issue":"4","year":2010,"title":"The autoinducer-2 exporter superfamily.","URL":null,"raw_pages":"195-205","medline_journal":"J Mol Microbiol Biotechnol","ISO_journal":"J. Mol. Microbiol. Biotechnol.","authors":["Rettner RE","Saier MH Jr."],"DOI_URL":"http://dx.doi.org/10.1159/000316420"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":79,"interactions":0,"matches":58317,"pathways":0,"proteins":58169,"proteomes":19308,"sets":0,"structural_models":{"alphafold":37191},"structures":2,"taxa":29447},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":28959},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}