{"metadata":{"accession":"PF01554","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002528","hierarchy":null,"name":{"name":"MatE","short":"MatE"},"description":[{"text":"

The MatE domain

","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"MOP_flippase","extract":"

The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) flippase superfamily is a group of integral membrane protein families. The MOP flippase superfamily includes twelve distantly related families, six for which functional data are available:

  1. One ubiquitous family (MATE) specific for drugs - (TC# 2.A.66.1) The Multi Antimicrobial Extrusion (MATE) Family
    2. \n
  2. One (PST) specific for polysaccharides and/or their lipid-linked precursors in prokaryotes - (TC# 2.A.66.2) The Polysaccharide Transport (PST) Family
    3. \n
  3. One (OLF) specific for lipid-linked oligosaccharide precursors of glycoproteins in eukaryotes - (TC# 2.A.66.3) The Oligosaccharidyl-lipid Flippase (OLF) Family
    4. \n
  4. One (MVF) lipid-peptidoglycan precursor flippase involved in cell wall biosynthesis - (TC# 2.A.66.4) The Mouse Virulence Factor (MVF) Family
    5. \n
  5. One (AgnG) which includes a single functionally characterized member that extrudes the antibiotic, Agrocin 84 - (TC# 2.A.66.5) The Agrocin 84 Antibiotic Exporter (AgnG) Family
    6. \n
  6. And finally, one (Ank) that shuttles inorganic pyrophosphate (PPi) - (TC# 2.A.66.9) The Progressive Ankylosis (Ank) Family
","thumbnail":null},{"title":"Multi-antimicrobial_extrusion_protein","extract":"

Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters.

","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0222","name":"MviN_MATE"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":598,"interactions":0,"matches":188649,"pathways":0,"proteins":99069,"proteomes":20019,"sets":1,"structural_models":{"alphafold":70770},"structures":43,"taxa":31326},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":45,"alignment:full":110794},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6z70","name":"Structure of the MATE family multidrug resistance transporter Aq_128 from Aquifex aeolicus in the outward-facing state"}}}