{"metadata":{"accession":"PF01549","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR003582","hierarchy":null,"name":{"name":"ShK domain-like","short":"ShK"},"description":[{"text":"<p>This domain of is found in several C. elegans proteins. The domain is 30 amino acids long and rich in cysteine residues. There are 6 conserved cysteine positions in the domain that form three disulphide bridges.  The domain is found in the potassium channel inhibitor ShK in sea anemone [[cite:PUB00030746]][[cite:PUB00033687]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Stichodactyla_toxin","extract":"<p><b>Stichodactyla toxin</b> is a 35-residue basic peptide from the sea anemone <i>Stichodactyla helianthus</i> that blocks a number of potassium channels. Related peptides form a conserved family of protein domains known as the <b>ShkT domain</b>. Another well-studied toxin of the family is <b>BgK</b> from <i>Bunodosoma granulifera</i>.</p>","thumbnail":null}],"literature":{"PUB00030746":{"PMID":8599755,"ISBN":null,"volume":"3","issue":"4","year":1996,"title":"Solution structure of ShK toxin, a novel potassium channel inhibitor from a sea anemone.","URL":null,"raw_pages":"317-20","medline_journal":"Nat Struct Biol","ISO_journal":"Nat. Struct. Biol.","authors":["Tudor JE","Pallaghy PK","Pennington MW","Norton RS."],"DOI_URL":"http://dx.doi.org/10.1038/nsb0496-317"},"PUB00033687":{"PMID":7660365,"ISBN":null,"volume":"33","issue":"5","year":1995,"title":"Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus.","URL":null,"raw_pages":"603-13","medline_journal":"Toxicon","ISO_journal":"Toxicon","authors":["Castaneda O","Sotolongo V","Amor AM","Stocklin R","Anderson AJ","Harvey AL","Engstrom A","Wernstedt C","Karlsson E."],"DOI_URL":"http://dx.doi.org/10.1016/0041-0101(95)00013-C"}},"set_info":{"accession":"CL0213","name":"ShK-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1059,"interactions":0,"matches":26330,"pathways":0,"proteins":12913,"proteomes":1018,"sets":1,"structural_models":{"alphafold":11217},"structures":10,"taxa":3324},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":136,"alignment:full":20286},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}