{"metadata":{"accession":"PF01519","entry_id":null,"type":"coiled_coil","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002862","hierarchy":null,"name":{"name":"Protein of unknown function DUF16","short":"DUF16"},"description":[{"text":"<p>The function of this protein is unknown.  It appears to only occur in Mycoplasma pneumoniae. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled-coils [[cite:PUB00039581]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00039581":{"PMID":16522803,"ISBN":null,"volume":"15","issue":"4","year":2006,"title":"Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae.","URL":null,"raw_pages":"921-8","medline_journal":"Protein Sci","ISO_journal":"Protein Sci.","authors":["Shin DH","Kim JS","Yokota H","Kim R","Kim SH."],"DOI_URL":"http://dx.doi.org/10.1110/ps.051993506"},"PUB00004470":{"PMID":8948633,"ISBN":null,"volume":"24","issue":"22","year":1996,"title":"Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae.","URL":null,"raw_pages":"4420-49","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Himmelreich R","Hilbert H","Plagens H","Pirkl E","Li BC","Herrmann R."],"DOI_URL":"http://dx.doi.org/10.1093/nar/24.22.4420"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":28,"pathways":0,"proteins":26,"proteomes":1,"sets":0,"structural_models":{"alphafold":26},"structures":1,"taxa":10},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":27},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2ba2","name":"Crystal structure of the DUF16 domain of MPN010 from Mycoplasma pneumoniae"}}}