{"metadata":{"accession":"PF01207","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR035587","hierarchy":null,"name":{"name":"Dihydrouridine synthase (Dus)","short":"Dus"},"description":[{"text":"<p>Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA.  Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archae.  Most dihydrouridines are found in the D loop of t-RNAs.  The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap.  Dus 1 ([swissprot:Q9HGN6]) from Saccharomyces cerevisiae acts on pre-tRNA-Phe, while Dus 2 ([swissprot:P53720]) acts on pre-tRNA-Tyr and pre-tRNA-Leu.  Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD [[cite:PUB00014304]].  Some family members may be targeted to the mitochondria and even have a role in mitochondria [[cite:PUB00014304]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"TRNA-dihydrouridine_synthase","extract":"<p>In molecular biology, <b>tRNA-dihydrouridine synthase</b> is a family of enzymes which catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of t-RNAs. The role of dihydrouridine in tRNA is currently unknown, but may increase conformational flexibility of the tRNA. It is likely that different family members have different substrate specificities, which may overlap. Dus 1 from <i>Saccharomyces cerevisiae</i> acts on pre-tRNA-Phe, while Dus 2 acts on pre-tRNA-Tyr and pre-tRNA-Leu. Dus 1 is active as a single subunit, requiring NADPH or NADH, and is stimulated by the presence of FAD. Some family members may be targeted to the mitochondria and even have a role in mitochondria.</p>","thumbnail":"/9j/4AAQSkZJRgABAQEASABIAAD/2wBDAAYEBQYFBAYGBQYHBwYIChAKCgkJChQODwwQFxQYGBcUFhYaHSUfGhsjHBYWICwgIyYnKSopGR8tMC0oMCUoKSj/2wBDAQcHBwoIChMKChMoGhYaKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCgoKCj/wAARCAD4AUoDASIAAhEBAxEB/8QAHQABAAIDAQEBAQAAAAAAAAAAAAYHBAUIAwECCf/EAEAQAAEDAwMCBAMGBAQFBAMAAAECAwQABREGEiEHMRMiQVEUYXEIFTJCgZEjUmKhQ3KCsRYkM8HRJpKi8FSTwv/EABoBAQACAwEAAAAAAAAAAAAAAAAEBQIDBgH/xAA0EQABAwMCBAQGAQQCAwAAAAABAAIDBBEhEjEFE0FRYXGB8CKRobHB0eEUIzLxBhUzQnL/2gAMAwEAAhEDEQA/AOqaUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSvOS+1GYcfkOIaZbSVLcWoJSkDuSTwBRF6UrxhymJsZuREeafjuDchxpYWlQ9wRwa9qIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKVjz5KYcKRJWCpLLanCB6hIJ/wC1EWmvt/cjSk220xTPuy07vCC9qGU/zOK/KP7/ALjMT1loK9ar01dWbpqB1y4PMn4aKylKIbbg8yUqQQSsZA8yue5GOMSrQ8Qt2Vuc+Q5MuB+KedH5t3Kf0wRgemakZrKZjSNFtvr/AAtwkMRszfuue/s4a1ttn0mdP6gluwbgiU64PihsaRuVy2D2SQoKyDgZNdAR3W32UusuIdbXylaFBQI+RFcq6viW5vqfelsym5kCTKEkuRCF4KgN6M9twUD+/vmttM1PfNKXb7ysaokO3uDaYDxJZcTjgqAxtX/Uk/XNUbeJiKUwyDA6hXknBzPEJ4jki5BXTFKgXSvqHH11Blb4rcGfFXtXHEgO704B8RPAO3JxyO9aLq91ac0bcm7RY7Y3crn4YdfU65tajpP4QccqUe+OMDBzzVrzmaNd8KjFPIZOVbKtqma5NmdUtc31Kx97N29lfCmoEdLRT/qUVKB+hqe9NOoN4hNLY1Q85Nt6UEtznQAtpYGQlah+JJ7ZPIJGeDxE/wCyg16LqceD1IiMttunVWFqnqdpDS91NsvN4Q1cQgLMZplx5aQeRkISdpI5wcHBB7VGXuu2mAsJiwr1KGfxoipSMf61A/2rniXbnbhIemzlKcmynDIfWe5cUdx/ucD6CpRaNLz3YttddSlLcxtbrTpPCkpVtJ+oOMj5g+tQpeLOIJiGysoeBxtIE53XU2n71A1Ba2bhapAfiudiOCkjulQPII9jWyqgNHXq3aKvsZtM8eFKWlqYkrARg8JXj0KTjn2JHti7UXy0qUQm6QCc4wJCO/t3qwoqwVMerY9VUcQoTRy6Rlp2K2VK1l/vlssFtXcLzNZiRE4HiOHufQAdyfkKruH110dOnGFbzdpkzBKWY8Ba1rA7kAegqU6RrTYlRWQyPF2jCtelVNG666UelhlyPeY4zguOxMJT8yAonH6VZ1quMO6wGZttkNyYjydzbrZyFCvGSsebNN0kgliF3tIWXSlK2LUlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpWn1RfWbDAQ8405IkPOBiNGa/G84rske3uT6CvQ0uNgvQLmwW4zUa1nOK4f3RBUTcp/8ACQlPJQg/iWoewGe/evKPaL7cmkuXm8Li7+TGtwDYb9h4n4iR+3yrbWexQLRvVDZw85/1HlqKlr+pPpnnAwK2ANYbk3Kyw03vdZ0SOiJFZjsjDTKEtpHsAMCqq+0tqJ6zaEZgwpK2JN2lJikoJCiyAVOYI7ZACT8lY9atuuZvtIvPXHqHbIDqSmNAt/it59VOrIUofo0kfoahVUojic4qRQwmadrQqww8q3ttxFLZDhKfFbGMBOMhJ9+R9M1+YVscclpEjxpjquErcy4sf7nH+1WkjUsDURtsLV7i0OwYngsraASklSgd5A7EpSge3BqVaH07aI2t7LJtcz4ggvObM8pSGyM/upI/WuaYdcgijODbPXK62R/LjMso+JoOMkY2F/FRDRGk5qJMa7JkqtiI58RuSnhQ49PcEcEdiOKxbpZLjqK73W5ByPMkuSCp4tHA7AJwCSQnAAAye1b/AKusztKzWoLbqxY5AUuGc/8AT9VMk/05yn+k4/KaqVOqhbJ6FtSS0pfkO1WCofTuawfDM1xhzhbI5ontFRcZwPAX2KtjSmiAnSV1u0qHvmQpYy2OVKZQgeInHuNxUPmkD1Na6+6tj/CORLey38OtO0qI4Uk1cHRduQdAQZUxDiXpjjsr+IkpUUqWdpIPukA/Qiqx110bv7mp3P8AhIQjaJRLoMl8tiIo90EBJJTnlOAcDg9gTPl4a98bHMGbC6rYeKxtnkZKcXNuyikO+2xccGXDwtsedSD3x64qwNcOw7d0e05CUFJuriGn4YQfM2DytSv6dqikj3PyyNfp77PcsPod1FqXc3keJFgR9qVjPI8RZJ57ZAFb/r70/fvNmd1DpyY7FvNsj4Ecr/gSGU5PhhJOEKGSQRwexHII2Q8NkiY84uRbP1Wqo4vDNJHvZpvjv0XOd9htFlx2Y6QkclSjznsAPme1SawaM+++n7l6j2eW2u3LAW++yds2OonzpUrkqQoEKxxt2nuDU66PIDNj1FqN3w3ZENkQIy0p8ipK+CU/qpCfluPvV+WK0M23TsC1FAXHjxURilYyFAJCTn3zW2konPg1PO97LyvrxDN/bG1r/kfj5rj19h6ZCixHpDzjEYER2nXCpDWeSEgnCc/Liujeg+k4WntERZrcdAuVyT48l4gbiCTsRn0SBjj3JPrXOV7lR7ZNucYOYbhzJEUFaucNuKSMn3wBV6fZl1C7e9HT4y3PFZt8wssr3Z8ikhe39CT+9aeGB7ZnB62caMbqdpjNuvovvXrR0d+yL1JBjpRLhHfK8NPLrR/Eo/NPfPtnPYVg/ZjlPvMakZ3KMJt1hTY/KFqSvfj54CM/pVyXaC1c7VNgSRliUwthwf0qSUn+xqlvs+S7lEtFustssshLSXHJF7uM1stoDxG0NM/zqASgE9gAfcVZf0wFQJW+N1UtqnPo3QuzYj39FetKDtSpirUpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlEQ1FZDQuXUGGo+Zq0RXHP8rzuEj9QgK/9wqTPuoZZccdVtQhJUo+wHJqM9OQ5JsJu8gfx7s6qafXCFH+GAfUBATj61sZgF3p8/4WbcAlSoDApSla1ghIAJJwK5Q6ia3j641QJNvjNtQoW+MxJGfEko3fiV7JyCUjvgk+uBevWvUStM9N7vLjuBE2Q38HFOeQ675QofNIKlf6apHon07tWpra+JV5lR5UYhJiMtoCwjHC9ysgg9uBwRz3FV3EA6VohZuVb8K0xONTIMBRq6W9mfMhyJS3g8qMtKXErxuLahgdvQKqR9IHry31LtEG0znW2HAtc3chKwqOgbiDkcZUUpyORuqy710gQi0qFnuUp6WxlbLUpLe1RIwRuSkEH29M4zWF0utdl0feLhcrxem2ZrzCIyY86MYjjHmKljJUQsEhHKePLUak4ZUtex5yBvborKr4lTzQyNi3PgrQ1fpa06vs4tt+jqfih1DwCHFNqSpPYhSSCOCR9Ca8NN6G0xpkJNiscCG4P8ZLQU6fq4rKj+pr8K1zp7YVs3ESkj/8Rtb5/ZAJNa1vqNCVNLbli1OxCAyq4vWpxMdP1/OPrtwPUirzkvGS1cyQ8C2bKcUPesa3zotxiokwZLMmOsZS40sKSf1FaC6kP6+sbJ7x4smUP/i3/wD3RrLmxXgbc2Wj0d1LYusK8C+xBa7la5i4jsVLniFwhRCdgIBJPHGPUH1rOXZbjqmUzI1JuiWhpQcatKFZLygchT6vUDvsHHbPbnWvXDTkDWt4vN0+DTKZS1HZSlAW8taQSpe0c58wSFHuE4zgVu0TdRXkFMK3izRVdpE3Cnse4bScA/In9fSt0kALbEYNt/x38d+y9EzWP0sPxfb9LSai+7IeptGaMsrEWK2qWue9FiISlLLDKFKBUhP4UqcKRk9zVjgVp9O6dg2JDy4yVOzJB3yZjx3PPq91K9h6DsPStzkVpcRgDYLxxvhRVXTvRy58ia5pezOy5DqnnXXYiFqWtRypRJB7nmt7a7TbrS243a4ESEhxW5aYzKWwo4xkhIGTgAVm0rCwXlyoZfVrv+rjpkyVx4EeGibMS0drkgLWpCWwe4R5FFRHfIHvUrjRWIUVqPEaQyy0AhDaBhKR7AVBOqkhqDKsL4srkuU++qK3PZnfBuRSRuCQvHO7BASeCePWqS1Z1G1Hc4gRAu8kWRSj4L6FoDzif5XVIAwr5YH617Uy8qEP3A6fn+SplPSuqSGtNl1eCfXNfRXDcKTqxgifp8387eQ/EaecT+4BBFXn0C6tydWyX9P6jUgXqOkqbd27S8B3Ck+ix3/eokVVzP8AJtrrKooTDfS69leNK+JOQK+1LUBKUpREpSlESlKURKUpREpSlESlKURKVEtda9tGjWkC4/EPS3EeI3GYaKlrQFBKiCfKMZzgnJ9M1JLdPjXKDHmQHkPxZCA406g5C0kZBFYh7S4tByFmY3BoeRgrJJxXzIqIa0mSJN+sOnI8pyGi6CQ6++1w54bIRlCD+Uq3jnuADiqU1Jc4EidOtukpktiyBXhrZXPeUiWoHlxKlKJCc8Y5BAzjmsZp4oGh0jrX8/ra/wBlKpKGSqdpZ5+m3gruuetI4uTltsEKTfZ7XL6Iakhtj2DjqiEpUcHAzng9qjqdf3q6JQqz6ekNRQpaHZS2zKRuScEJ8I4VznnOKjfSKw/elqudpW5Ig2tp9Dr7DToUZW9PYuBKSlICcbRnv3FXZEisxIrUeK02yw0kIQ2gYSkD0ArKnka5olvqv06fUXv9F7VRspnmLTkd9/173VbXS+3a7WpEK/Q3rBa5TpjypykKBU2fypHdsq/DuVjGeMntZUNlqPGaZjNpbYbQENoR+FKQMAD5Yr5Lisy4zseU2h1h1JQ4hYyFJPcGo100dcFgfguuKd+7Jr8BLizlSktrITn9MD9KkOIey4FrKK4hwwLKWUpTNaVrVW/aLgMzenyHHpDbJiTmZCELUAXleZOxPucLKsf01UGkFPW903GE+tiRGSShTZwf/BHyPBqQ6usmsequpHLtbI8dGmIji41sMiUEB1KVbVvBIBJ3KScEgeUD5k+yen+qbJapbjtsTNBQQUQXw4v6hKgnP0HPsDXP8SimlkD4mnHZdXwiWCGExzPFz0P2U10j1jtE92PB1CPuy4OqS2HTzHcWTgAK7oyT2Vx6ZNWkttDn40JUPmM1x9oZ6zq6h216/wA2PAg21xcuQmWrwlBxsYSjYrkq3kHbjPlrorT/AFU0rftQtWe2THnXnkktPKjrbacUBnYFKA82MntzirGinc6MGY2P1VRxGlYyYinB02vjICnCUBI8qQPoK/R7UHaoh1G1mzpO0F1CEyJ7mPCYJ/LkBSzjnAGePU8D3FgGk7ZVXcXAJtfubb+JWbdbFDSt6bCmLs8rBW5IjlKUq/qWlXlV9SP1qrLt1Bfg6lKVPwJNyERUWNKZylC0FQKnSg/hwQnv5eOCRVZ6h1TfNS3AvRn3VynCWy2lONp3bUp9sZI2gep9+as7QOgokLUb9jdSie5EablagmPjd8U+4klqKkH/AAkglZz3JTnvxYM0RsDnHVfwt5+PgFHDpZZDFKLAb5ue4yMfdTzS2mIOn4/3pe3o71zWPEXJWobEf5Se5x+b9sDive8dQbPbkfwmrlPVjOIcNagfos4Sf0NfiJ0103DabahsTWI6T/0kz31A47AFSipIHoEkCsbW9jttm0hdplttTJlhnZ45aLziEqISpeTlR2pJV+ladUcrgZCST5C33WuTnM1OYABk9ST18FWeo+pbsrX1nujcKeLdb2lqZhuOFnc64kjc6U5BODwnnHPqTW8b6xz1SGt1nioa3DekvKKynPO3gDOKk9otvTu9NCLCatkhSMM+bLbjpwOecFec8kZ5zX2Z0l04tCxB+NhKUDhKZCnEA+mUrJ4+hB9iK3l9O06XsPr/ALWcjJpOuntbOPHA+YPoprZLvAvdvROtclEmKtSkhacjBScKBB5BBBBBrOyKpzSFvv0OIxZLHfnW17ZC5DMhpDiYxS6UZS4BuIUoEpB5xyazxoXUrMpEyBcYse5JUFGWqbLe8THcLbWooIPrgD/tUd1O1pILrdv59lS2Mx8ThdSXqXIjJssSNKU0lMmcwCpZ4QlCw4tX6JSf3rlPUFku6OodxtOnbTLkJmuGXbmPBIJjOncgk8AISSRlRwAOe1dIaRgSNSXqXK1UpcqRbXPBEZ1IS007k5KUg4UnAGCRz+1YX2lJ1zgdPEKtby2G3ZrTMtbatp8FQUAnPsV7B+uPU1FromCLQckZ+fsKdSyOhkDGnJW2tGvrPYLHAh6y1Pa3L60yES1RcqR4g7jyjGR29O3YdqgnU7VWjEuW7XWmJUSVqK3SUBZjkoW+weFocBAJG3gEjI9PUVTFv06JFrM+bdbVbIZyEeM94j7p7YQwjKvTuraK10aF4qRCjJW87KWEAJT5nVHhKQP14Huap31j9NiB79VZRcPi16gTjfa32/K7xiPtyYrT7CtzTqAtB90kZH9jXrUH6O6gVf8AQVvcfjORpkLNvksOJKVNuteUhQPIOAMj3NTg8CrZrtQuufewscWlCcd6Ag9qgfVfVq9PWhqPb5rUS8SsqjF5vchQQU7k7j5Uk5AGQe/6jeq1RaYcW3quNziIdl7EI82CtZHPl7pHvnt615zGh2knK2ch5a1wG97d8dfL9Fb+lBzSs1pSlKURKUpREpSlESod1G11C0dCQlQTJukgExooVjIHdaj+VA9/U8D5TE59K5I6/s3G09WZUi4LK4lwjtuQl48obQNqm/bKVZP+sH1qPVPeyIuZupdDHHJMGy7KVIfTrmG8J7xN83FaXCcJI9EJT2SkdgP3yalv2fmrvDZvcGSFC0R3gGAv/DeOS4lHy7EjsCfmarDp9DVNcXcpPxibbEG90xNnir+Sdyhge5/b3qwn+uVgskZpiDp+6/BsjGElpJA9eN5yfXvyao+HWEpkkfY/Uro+KhzoeTCy4x5N8veFKettjuNz0oqZYFLRdoSXQhSBlRacQUOJH6EH38vFct2h6S0lDD8dbbicJA7j5YV2x867T01e4WpbBAvFsWtUOY0HmysbVAH0I9CDkH5iqC6s6JkWHUUi4QIRGn5WHfEbxsjOqVhSFD8qSSCk9sqI44qbxOAuZzGi/f8Aar+DVIbJyXmx6fo/j1Wws+rpGgLAzFhw7ZcJMhReekJmlWVeicBPAA47nnJ9a3Gg+trt91dFsV4s7ML4rKGZbUgqSHMeVCklIxuwQDnvgY5qntRw1hpDfhFpnYAglO1Sh/MB8/etdbre+iyxZiC4hfjLLb+4lQW2vynPuCBVfTV74mi5wMWVpV8LimJsPiNze5yfJdf6g1GzanmILTZmXmUCY0Fo+dYH5lfyIHqo8fU8V+9JWhyz2tbclxLsyQ85KkrQMILrityto9h2H0qp+mXUPTUK1zblqSehOqZ8p1UwJYcW5tCiG0AgHCAkJwM4/Uk1vLj1ntjSFKt1smygkZy6pDI/3J/tV8a+JjPicBf2Fzv/AF9Q4lkbCbbnxVrVh3Zp962zG4iyiStlaW1ZxhRSQDn64rna79Y9WG9xJrTEeJa47oW5bmkBa5DefMFOKGQraTjaBg4zntVuXebG1k5Zrbb5RXaZzH3hJU2dpdY7JRnuAVcK9RjHvWymnjqSQw7LVPRTU5HNFr+qzemMmPI0FZBEwAxGTHcSBgpcR5Vgj08wP716a51XB01ZZ7qpcYXJDClRoylje45jCBt78qI/TNRW82+boC7MOaRjoctt7fTFVAKuI0lQO15Gfy4BKk/L9sbq5bomntBeK2yh2W/NZEiUtI8R5RJJKj37+npWUoFPTl4N7DHoOqyijZPUC+zj+VznGtBjvhb6lPuOKy664SpSnCclZJ5JJJz9a3sNpyM61IjrLL7K0utODuhaTlJ/cCtxp2MnU16i2qJGUt59Y37OyG8+ZavYAf34FbPqXpG5aXuDzjbEiTZ3FZYkoQV7QedrmOQoe+MHv7gcjoqJW80A4K7TmU0D+RcZG3v7LoHReomdTadi3Jnalak7X2x/huD8Sf8AuPkRVP3WHHvUez36+Q5sqHd0/EyLg2+fCitlXlZDYP8AJhOTnuTUF6bah1jab+4NKWO43FqUnw3m1RlhkK/KsrVtSkj3Jxg1KdXR7vpvR9j0xdpMRxbTBkFuMhSfDKiobSokhQGVAEAfT1rseFuknAY7BO/fHQef4XB8WihpXOkbZ1v8Qc5PU/8Az/vssLRtsuOqdYyZWkUxY8W0ONyQqa4txKnVbghO7BKtqMnkd8Hjg1aMO5yY+pLpf/ut6K02pEG7s5Kx5M7H0HA3bQeePwKSeOcaPpPKf0/piyxrfYJs529rfmPSk4Q22QrYkKVjgbEgjOOO2ScVJtP6inM37U1tnW92RPafS8huINyFpU2naN6sADaEDKgBndjNeTythnDWCzb2t02OPDvjqofMlY2HmG+sm5xc3H/sd9xi/wBlPIz7Ulht6O4lxlwbkrScgio9rqS6uBHtER0tzLu8IiVJGVIa7urA+SAefQkVHNO268my/ekGSrSnjKUt62TGkvMNkHG5IJSUA+2QPljFSaxadei3Jd1vFyculzLfhNuKbS22wg8lLaB2ye5JJOBzW5ugfGDfw6+qmOYI3EXvb3vt9VEdYdJbZOjeLYU/BSmxlLYWQFEdsK7pP7j3HrUXs3VC6aWWu36mjuzEW8hqWCnw5TST+F0A8OJ9DyOcEEggVfNUx9paHMRp+Bd4kCI7HguH4ySoZfS2ohIaA7KQoq8wJ9BgZ5G+OfmARS5H1CiGPSS5psDv2v3/AH3+qk/SmRDuB1BOZeQuW9NO9vsttojc0FD0yFk/rj0NWB6VxVp3VMq3anjXtt91uR44cdCV7d6SoFSFY4IIyMHjtXY1ku0G+Wxi4WqS3JiPDKHEHP6H2I9RWNXGQ7X0K8jnbI5wAtk/dQfRi3Guq2s4pUdm1lwp+ZyoH9lipB1L0wdY6FvNhQ6207MY2tOODKUuAhSCcc43Adq9LXpZmBrS9aiTKfW9c22W1MKA2N7EhJI9TkBPf2+dSM9q0yvDyCOw+ylPdc3Hgv59SrTdLHeJVtucTwJ8ZfhvICkrAOM8KBwRzW30/c75bbm1cdNQnZUyGSreiGqSls49QAQOM81O+p9ssmketEl/VrU+TYbkFXJtuKkbnVk4U2TkYAXknBzhQr9a06yJuljFh0db/uKyhO1ZThC1I9UgJ4Qk+vqfpnNE+INcXPxbZX8cxewNjzfcm1h6KU9EOoL9x6hXKNe1MsSL1HZeShHCBJQDuSke5SofqiuiK5k6a6D39LtR6iuDPhSpDPj219SMOsIaBX4zau6So5wR3CQexq5ej2rXtZ6Fh3KalKZ6FKjStowkuoxlQHoFAhWPTOKm0riBodvuq2ujaXGRmwNj8vY9FsOor0uPpWYu3Wpd0lLT4KWUICykLG0qx3IAPYd/pkjLa07aH4sJMi0RP+XKXG0uNJUptY5zn3B9c1uyM96VJ0Au1FQxIQ0NGPH5fb8lBwKUpWa1pSlKIlKUoiUpSiJVcddtDOa30dst7KXLzb3RKhAqCSs9ltbj2Ck59huCSe1WPSvHAOFismuLSHBc26NalWizXaJdoFwt7zjBQ2iREcQFHHYK27T+9QN2xSrgJSlx3QxGx42UkcnkJ/bk/L61ffWDqYNKuN2W0bV3uQ14qnFcpitkkBRHqo4O0duMnjg1/obVSQlyFdVl5l9RWtbqsqUo8lSlHuT7muWrIY6V+ljiT9l2VDUTVUbpXsFu3e3ZZ3Q/WTOmrNqW23TxFRoDLt3jpbTlRQB/GQkfXaoD+tWeBUNuGu7rqm8IuVxdKG0K3x4aFfwmE+gA/MrHdR5PpgYAsODoePKgaovsZC0xHLVLjQAoEFwuNELcA/l/KPfk9sZorRMV6axB3ZCXAgd+T9KkVDpf6RokNvytFIIDXPdEL7endWzroxrlp2LdVPNIXgJO9WCr6D1rE6aQpN9tT1gaihxBcW6HlDyxws53KP7kDue3viFa6sj0fVMp+G4G4XlLUVb63ix5QCEqUOxIJ+WcZNb6ALZO0G78GW3nmXgJAP4tx/mH+1V2ljc31DrbCsm63N0gaT0v0+R6K0tW9PNLXtiDb7FdIES+wWQwyPHSpTyU84cQDknOTuAzye/aqj1Jap+l7qzbLw223IKBIwhwLCk7iEnj0JB7gdu1RG4WoPvtLjp8BTCw4l1obVIUOU7SOxzWf1A1A/fdS268vr3SpsBtmQ2BjY+ySleB6JUClY/zEehNWEnJq2FzRZw+yr4ufQvDHO1MPfe/8+qkobTeShllpbk5w7W22xlTqj6Ae/z/AHq1tG6cu/TlmLOuJfusRbS2X48NsuG3hSgsFA/EtJVndgcE5Axmsbo8zpvT9oRPmXFmTe30bnFNtrWI6T/hjA7+59/lVpWfUlmu6vDttziSXectocG8Y/p7/wBqmcJhZBdxcC49L9FC4xWSzHQGEMG5I39eyry76+skjXdjcjqlXCPHiSVttw4y3HVSDsSEhvGSfD8Q57D5Vj9RJ8vU9h+FvET/AIYsS3EuqlXBSVyntpyEtsJJIOcZKiCPb1qV9W1W6Jo2Vd7kuQw7bFJkQ5EcgOtvkhKAknjCioJIPBBOfcc13HUNw1FcFXC8yTIluADIGEoH8qE+ifl+p5rZxCpMQI3vsPDx9hauGUrKgtcMW6/rp87+SsrTHUjSOh0IhWqw3IQnXEiRcXS34q8nG9QzkgZ7DGBnAroDj5VwzqC4QGoT7chzekpKVeH5gPQjPauxdA3F+86EsU+Qh5uTIgtLcDzZQrfsAJwfc5I9xinDZ3ysIeLWWvjNNHC8OYbk75uVIePeqp1dbH5nUJybL0zcL7DYjstRkxJDAa3gqUoPBa0kYJSQOQQfXtW/haRvXjMTLpqmZInR3FKZQltCWAnIICk4CjnHJ3djtHHJ0hublh1HO+67VLdub7iPj4qV+IysryUONKPKcknPGPMc/hqWK19OdTm2B/Xh1/G3Zc3VSMbGxzxuci2R8r3/AN22WXpLUKrTfZVkvFpm2luU8JENLpQ420HP8MqQSACsK2+nOPasqxaqYZ13ebLeWVQbk8tDkcEbkOM/gbwscc4zg45JHccx3UL0p7V19VfG0Jhxre3F3x1ZDS3iFNAAgFRDjYO/3UngDOM+16jY1J1As0W4Wd5ppiAqRHmyI5SiRK8hUlpR7hA3HHqQTjygmTI01J1R/C5uSD22v3yNvr1Wb5WTkFmHA7H5X72te22d+ym2r7VAvGm50S7RpEmJs8VTUfPiKKPMNmOSrI4HqeKh2kLne9R6WkQrUVWlMdAjsTJjJW6EFPkISCAVbduVcDPYGptF1Ban7/KsTM5py7RWkvPRgTvbQrGCf3H7j3rDsunVW3UV8upuEiQLmttfgOJG1nanbwfXjt7DjnvWqSFwc0m4/I/SsIpgIy0nbI6i/XG23fstjp6LMhWWHHucz42Y02Euv7du8/rz8snk4ya8tV2OJqbTlwstw3fDTWS0op/EnPZQ+YIBH0rXXfWlqhzZVtju/FXdlKNsRsHK1LUUhIOMdwc+1fGrBcprfjXa+T2ZS+fCgLS0018gCCVfU5qQ2PSAXGy1OaXXc7F1yx0vsSmesUbTuo4bElUWQ7GlR3mwttzCFYVg8FJ8qhn0Irql7SzUWYqfpx0WqUsDxWmkZjyMDA3t9s443Jwce/FUf1ZD3TzqPaNTJlG5XeS3hAdQlAeQ0nYS7t7Kw4nzAYVjGBjmTdPOtq7lOTD1fFiQEvKwzMjFQaQT2S4FElP+bOPfHevJ6tkb2t1ZI9PqlNQykOfG24H6VgzNXCwPstasiGAw6oIbuLWXIpV7LVjLRPpuGPnWJqTqvo2wja/emJkjGRHgH4lZ/wDZkD9SK8uuEl1vpndmozi21SvDjFbZwdi1gLH0Kdw/WuXY9oahkBhsBsfkHp9Kra7iDICGgZ+itKDhhrG8zYXsrovGr+nvU+AIutLZPt6oq1KiPOBW9IVgFSVs525wMpVxwM5xxpdX9PdGaI0Ob/p1tV6lPOttRZM2SJDTW7PnCE4QrABxuBwce1Rfwl2NqSmchcSWE7Q06ChwZ/pPP/mo7fIN7scFMy9WCTCtExYS1JkNBK0L/wAmdwBGc5HbmoEVdLPqa5m3VWUvDYKYsc2SwPTv5LcW7U9/mpkJk3u5OpdSW3kLkKKVpIwQR2wRxU16W9QomjGkWabDbRaHpCnDJbUd7KlnkqBzuT27cge9VXY5UQXKOiTPZhRn1eG4+sb0I4OFEJ5xnAz6A1IOpuhdR6b065eVIh3C0BAWuVBe8RKUq7KIIB29uRmtEAqebrZspNSaQw8uUC/v0XYLS0uJSttSVIUNwUk5BB7EH1r91F+mK3XNAaeL696/gmwVfQcf2qUV0UbtbQ7uuQkZy3lnY2SlKVmsEpSlESlKURKUpREpSlEXOH2rLMYVysGp2EYS6TbJJHqeVtH59nB+1Rvp/aEzWZc6UspVDQHWmihKkqVn84IwR8v3ro/qDpSNrTSkyyy3lRw8UONvoQFKaWhYUlQB78jB7ZBIyM1WKNB3DR1rnuSbvbHoj6Q2VLacbcKvQISCck+1UvE6aRxEkY81e8Mr4YInNnfpA+Vuqht26saxhtLSJkGW2QUqakQUqSsHjHlKe/avLpbpK4SLFAvcBpmbFjuLYkx21htyMtB7ec7VpwUnO4Hnsa3EXQbJ06XvG+IuOBtJSAGwPyjHc+6u5qrIV1lINxthefZiGUpTsPeQhS0+XcpPqcJHy7VAbPzWlk13AbFb6HiFJWvc/hzg3Njjcd7dj02Pkpdf4z9xVIuACkxFrIQsjlf0B7D51iaAVZrbM1AL2p8RVQ0ONsMOBC5TocwEZIyT5u47DJ7VutNT25cJdskbllwYZSlJUpSv5Ugck/IVHuo+lLzpJiz3S6RkMxZri2Rhe5bK8ZSlzHAKkhRABP4SDWika9xOltx9FdVr42hoe6xJFrYPopjZbbabtZTHYCWpilFw+YnzH0BPoOw+lRe7aAuP3RO1E2wtbVrkIZUG07itBP8AEWAOSEeTOB6q/lNYmlnpcl/fEJSGsKccyQEJJxk4/wDo71OJXV/UdoiojWm12Npln+G20pp1Z7+4WMk+/qTmsqRrGyHnG3T5/pRqyoc7+1BkiziD0Fzt5kenqF6dNJrHwcjZJaJCTja6P9s1Xmo5akTnZLbjjUhDhWh1CilxCgeCFDkGr66Y6itOsdPXCRqux2e23e3ObJ7TrCUoQkjKVneMpB5GCTgpNQLqsnRFyYQnTtuX46FeZ+ISzHUM8p24wrPukD6mt8lC2Bok5gt0/hYQ8QfUSOjERBO/UDzOFn3W63LqD9mC5zpag5dYGXXHPw+KI7iVlRA7Etg8e/NbLoB09gjT8HUl5Q3MmSR4kdpWFNsJzgHHYr9ee3HY15/Z4CZ+nNXWKQpHhuPBWzHAQ6zs7e2UEfpVWWqRf9DXGdaUTpdvlsqLMhDS8JWccLx25BBChzyOaspJ2NYyZ4uquKme98tPG7Sb/T3ZdR317SNtuCJt8Njjz0+ZL0lLQe+oJ81bGwajs+oW3l2O5RJyWVBLoYcCi2T23DuM4OM+1clLV4291aipw8qWs5J+pNS3olf4+nNVXdyQ3JeizIiEkxGFPqC21E8pQCcbVqJ9gK8o+IOqJeWGWuva3g4p4OYH3IXR96dms2qU5ao7ciclsllpatoWr2yeP3I+o71VmpI97msTHdSqTZ47qt4bSoEPhKMBKXEqO1YAO1KuFFShzirUtFzg3m3MzrXKalRHhlDrZyD/AOD8jyKgfUfUVum2Q2y1PN3GY64lQ+FIdDJbWFHJTnCuDgd+CfQ1LrG6W8y5BbsPH7rkeIRXiMhJ+Hp0v0v18PwqZXI+DEhn7wIiqSW1qSFFK8DLe8AlI7g4JODVpWq82bVOi7HZ/ilNTXpKELSlwFbRSrKl9iMKzgZ/n+RxJbq3arBoj4bTdpgpRdFhqLDS2A06896qA9AMk/JOKqzSMSy6ThayskxzwpMV0twpT7X8b4ltvyFHGQSAhaeeQfbNWU7HVFPI6Q3djoLEC98dMHrfPYYWkUb4o+U06uZi1t98Dte5A3yb+CsjUdgt9rudld0w3AteopTxjofS2A5IZCCpzxMD+IAEpUSrPIHIJzWMuLNt+qZtmsd2nzLjdimVNkyFAotzIBGUgADerOEj0AHYAGt3a9EwnrratRXp12fqGG0Uokh9fhoCgfKlAO0gbjyRk5yfTEKidQrVpDW+sYOoYlyROfuCXm3245dSuP4LYbAIOQAQs47cn51Dkc1uiQEjAvfpa+Bkja318Fc0LHfGWg3IHw77eAxjfHYbhTrTGgbPp2/3G8RPiHps0p80he/wUhITtRxwDgk/UgYHFZHUHVcbRumn7pJbU+7kNR46OC86r8Kc+g4JJ9ADX60brK0aujvO2d5ZWyQHWXmy24jOcEpPocHBFQrrywmZ/wANRVOJBXKeUlGRuUQyrkDucZ/uKxqakiF0wN7BSaenMtS2GbFzm6511RcblqK+StQ34Bcl1SUlKFEpZbzhKEA9kjP1JJJJJrLgttqaC0FK21DgjkEVJ9Qaa/8AT08Mbi94YKRg/iBBH+1WvE6V2S5dPrNGt8lceY3FQtE9KBl0qG4lxAwFDJPzHAz70kcDq+nMrT8YNvMW/wBroJKpnDKoQuHwFtwRuDfPpt/OyqGRrSa1pRzT0p0O2/ehbJWfMyEnO0H1T8j2rX6fzfr7AtMIeLJlupSEp5KUZypZ/pABJNWLaPs+vS5yl6rvu+Gk+WPbUFsuf5lryR9AM/MVculdIWDScQRtO2qLAbxhSm05cX/mWcqV+pNbo+FukDTM7b7LRLxpkJcKdu+fXuto/EjyHmXX47LrjJ3NLWgKLZ90k9j9K5h6x6os1763NWHV/wAUNL2pCGSqM9j+M4kLU4cDOBuSggcjafpVwdeNZI0doV1Tb5auFycEGMod2yr8bnHPlQFH67R61Ucj7Nctdo+MtGqo8+Y4gOoS9FLbTuRnhwKUcHPBwatZbn4WhUlNpZ/cee49/NZGu+hMP7gcvPTye9PQ2gufBLWl/wAZOMnwnBzux2Sc59CKjHTrXxjdMdS6auzEiezNb+EtjPYuOPZQW0k/Mg4Hb9ag8pvUukLs7ZX5E603BtQSY7ckoCirsoEHBB9FCre6FdOp6epM+dqhsPKsCg2g+IHG/iVICuDxkpSvOQOFfoaiC7njSLHqrE6WRnWdQ3F/D39V0bYYCbVZoFvb5RFjtsA++1IGf7Vn0ApViAALBUhJJuUpSlerxKUpREpSlESlKURKUpRErnfqzqCcepcu1yssMQ4zaoIV+FaVpyp3Hqd4Uj/R8znoiqL+0taFR3dN6rjNtKchyDCkBxO5Km3OUFfyStOOT+f51EroubA5qiVtK6rhMTNzt4nssbSFzekOpa3Q2N6N5L0keGhs9lKUcd89hz8hVV9SLJ939Wrq1AktyIkhtmX4yVAglSMK/D/Ug8fMfWp7otpt7TNzW+2h1xQK1lbOAlRzkDPfjByPfHpVay2VIuPjQm0B0DC+PKU59cf29a5mCVrGOY0ZPX+F0HAP+MDhjRK5139R072Hl9VOtMX2VottuTbGITsh0ZWqSzuWR7BYIKR8hU+k6msXVzSNx0tcCm2XiS1/AbdWFAPJOW3EK9cKAyMA4yKhekNJ3TXlnVNgO26Mll5UZ1Dry9yFAA/hCOxBBHNTWxdCbWw+mXebnKlSwQR8L/y6EkdvVRPHzq14YyoaDzL6bY2OenUY8enYqXx59MWXp7c2/j9VX+h9K6oss1NudtK2LiY6gWy62oK9zkKIAODgnn5V9uGmZca/i3XBiEJqVeOltL5dUEkHY0ccZBwrvnGPSp2LwzovRuodUTUuXG/x5ara3KfJIdUFBpvH8qPzH17jJzVOwb3MW+9KMtxcp9RcceUclazzuP6/tUGqgjY3WL3cfkP2o/D31XFo3Sl2nAAAvsDcg5tnILhkC1lpUrV/xFdETj4slqUtpS18nyn/AO81M7a27cmkxmWnHnlcIbbSVKUfkBya00LTL9x1BKudxlMR27nIXIjNtupUp76+qP1Tz3Ga3EDUEOPYUTrEh+DISsoCz5XULHfzevt/uB2rTNTlw1tBLW6QbdL7fY+C2v8A+Tf00jaSOFzpSQLbBt+562z/AI3BsRqV2dHtFP6XhTZlzCUXGfsCmgQfCbRnakkd1ZUon6gVz7OtV31N1v1HZGEqEx26vErczhtnOQs/07MY/THpXQnRbXD2tLBKFxSj7yt7oZfcQNqXQRlK8ehPII9x86rzq49ctDdXGNSWFQZVd4aUyPEQFoeU15VJUPbb4XYg5q+kZEKZoH+IWuF85rH6razfy8PRb64dCWJCUNx9QyG2QBlDsVK+fXGFJH7gn5ms/p/oW0aA1x8N/EkuyohVAmyMbg5n/mGwAAASA2RxnAIz3zr4fWx/4cKk2FtbmOfClbR+mUmtBqbrK7d0s21GmAXpDyG4a0zyHGpJOG1pIR6E+ncZHavaSpomOtHi+Nisp6XiDm/3xcebf2ra6cNNCNfpcYIEeZeJL7ZR+FQyEFQ+qknPzrbQLbZ9I2iV93xm4cMLVIcQgnBUcDjJ+QAHbsBWgsFk1TZLPEtcN+xiNHRtCy07uUScqURnuSSTzzWHq+13ORDiRrldkyZU2QmMw2yz4LKCQSpe0klRCAogE1bhgkcC4hVhALiGuwV80DFVdzaZi/NAtEdTEfPZx9X4lj5BOAPrWh1noVzqNeZ8+33f7vVb5JjNhTAdakKShIUHBlJyCCAQeAfXtVg3ay3FrTTNt0jcWrPIYKA287FEhOwdwUkjk+9R+16S1daLC5brdqmAgpQ4WnTazv8AEWSrcpRcOfMfbtWwyhxc69unpe/vzWqQh5Lu23781Bf+KNcdObvFtd++EuFrfUEMPyVqS2BjJCXwMjHbC0k9sZFY92v2n9Y3tyfdoz8BbcZpvaVIc3KyskhSTynBT3wflW56gW7VydOW6HqWbbJ0AlDUiQhk4DpwAt1GPMBlWMbQVbcgcVVXUy3M6L1i9bvHC2JTDUqOooDaVAgpIQB3SCn3J5qi4pK6cPjaNrdN8nO+xHh06Lb/AMfnArOUbiwOSR4WA3v1ypzFvsDR8kz9HxXLncH2lxfh1EpQM4UlxZHO1OxXA583pnNVXqyTd75eheLzcZEi5N8JcSotpaT6obSPwJ79uT3OTW66f6ijwtRokOYcbDK0KHcebHNS6+wtKztU2iIu4fDNXFYD/h4w0k9iSeE7jgD2znsKp4HVDi2nj+S62dtNFqqZji3+R8OnvfZQeLNvkSQw4zdZa1R3EuNh8h0BSTkcKHPbsa6F6K3h2XplmFNQhqSkKfaQjhKmlLUPKPYKChj04qqEaijQ2UMuW2P8U0PDdJAPnT5Vf3BqU6P0o1q/T0u8RL3eLLcGpT6EGHMLbKThJJ2/lBHBKce9S+D1LxI6F2xH1HX8LRxmCMwCQ4zvvvdXrXxakoQpS1BKUjJJOABVZ9LLjEhN3RiZdnUJU+2piNcZ6n3EApCdyXHOVJWrJAHY5FTrU0Bd305dbaw6GnpkR2Ohw5whS0FIPHsTXRSMLHaSuTc3SbFcxdVbteetCZEjRlr+O0/YHlDKVASHypP/AFA2fMUkA7QOcDOMnAiPT3q3qPRSUR2nTOtqQUiHKUdqP8p7pI+X6isHp9qm/wDS/UsptEfZIbHw06BIyAop7Zx2I7hQ9D7GsrqJfbJqnUKr1bIxtLkpvdNjuJKkl4H8aCkY8wxntyM+pqqkkzqzdXUUJtpsNNvd7/cLK6i9RHOpcq1qVphoToboaZdZeX5lL7NrI9CoZAyDwcdzXWXTrTr2mNKRLfOk/F3ElT0uR6OPLOVY+Q4SPkkVT3Q6Rc9YN2SP8C2zpTTai4JCmtqpswAhGB7ICiSfcJ9e3Q+RUmnaT8Z+qhVkgb/ZZsD028Pf8pSlKlKAlKUoiUpSiJSlKIlKUoiUpSiJXjMjMTYrsaYw1IjupKHGnUBaFpPcEHgivah7URUZ1GVo7RrirVZbYVXd5IcWwia+hiOg9lLQlYGT6IGOOTgYzHbNaLfetLriw2wi4tEulZOVOn3P+2Kh3WONIsXV+9tyXHHEziicwtfdTa0hOB8kqQpI+lb/AEKGI7KrpeDc27cjjbBSne575JUCkfTk/LvXLV7CZ9NgB6D6rsuHOAptYJLt+pz2t9FNvs9QblEuuoHC3stakoQsqHeQkkYSfkk8/UVbmprumyWSRNKdziQENIxne4o4QnHrkkdqqW4dXrbFZt1q0lGbtbKVkPSLlEUWIzCUklQQ2rcSVbec8ZKj2NTu3WK+3W5W+fqu5256PDV40eHbWVoZW7jyurUtRKsA8AYGea6OhjYyJo1XH3XOV7nSVDpJG6b9Fobt02nStGNWC33JEWLNSG7mw+gOIKSnG5vIOFpIB4I3EZyDzXOOmbbIt+q37VqBASbfN+FfSs7Q4Qrj6hQwfmDXb+OK5s+1bGtLF10+WYLAu89xbkmQkYUtppISkLHY8rABPIAxUeupxJGSMe+iz4ZU8iRrA0W7AW39/pYXVOIhm6b220IQtHl2AAfLGKgl0cuj8XEt4vqb43OEAo9gVev68/WvK3AFlKVZIHYEkgfT2r3+BkT5DUWBGckynleGy02MqWo+g/8AvA5rmmCzrb5XVvhY9rZHAXaMHt3z08VdX2VbaY+krxOKt6pVwLZXjAUG0gEge2VEfpVm640jA1hZ/gbgFNuNq8SPIR+NleMZHuCDgg8Efoa8emGmnNI6GtVnkLQ5JZQpb60di4tRWrB9QCrAPsBUprrWRjlhjguKlmJmMjD1x6bLnu49IdRxErTCchT0ehSstKI/yq4z/qrT6c6SavVrnT82dDYhW+BNbmPOuSELKgg52pSkkkn54FdOUxUaPh0Mb9bbqZLxepmj5b7fL2E9KhmtHvhtWaKek8QDNdZUr0S+tlQaz9fOn6qA9amdYF8tkO8WqRBuTaXIjycLBO3GOQoH0IIBBHYjNWLDpddVjTYrPFDVJWzqbebcovvR49300ypbbcltwGe60gkeOtAOAMDIBCSQM5GatuyXy2X2IiTaJ0aWypCVgtOBRAI43Duk/I0cwtWTo3NyQoVrKdP1LOuum7REcYXBR4r8iS3/AA3ApshKUcHJJV/8T2raW2JY9QdPrSrUUOBMt5iN5+MbStCeAM+bseBzUywfeue9YagiQ4blss8wybI06pcZCSFJ5JOAR3QCTt+Xv3rZSUTZ5C4nzPh+1W1krad4mY3JFrX3PfwG97L11L0TsLWq4ETR8idapElJdkNlXjsMsJ4KgF+YKKiABuI+QFTjSvR3Stjc+JlRV3q4HO6TcyHcZGDtbxsT6+mecZrE6FXKRd4NwkXBwOS4/hRBkYIZSFKRn3/EoZ9cc1adYSQshkOkZ2J79ffkrH+pM8TRe7d7ePvC506r9KrjaPEuei4z06ASVO25vzOsfNod1p/p5UPTI7eekbleovT+Fpq36a1H94TnlvXBaoK2ChKl8oQtYCQSkJG5RAAP7dErkspkojqebS+sFSWysblAdyB3NRrVHUHSul5aot8vkONLCN5jle5wDGRlIyRn0zjNQxTxskMowTupra2VzGxEagNvsPOyiupNFXfWtiRBvtr07BitpCYzKS67Ii4/CUvp2gHtxtI98iopB6l3vp3Pcsmsku3mDGUlv4xACZTG4ZSHE9nEkZ2rHfB9eB4a0+0KXp0KD09iR5hfwlcue2sJCicBKUApJI75Jx8jVd9cn9b2zVEdnWZgTWnGCIj7DIQh1vI3o3AA5BxlJ7ZBHfNZzVAcDpGR2959VnDGcNmHwn5+/eVcF/u3SPqQ0iTd5kduchG0PEqjyUD2JH4h8jkVXbPS2xaj1CHdIXCSrSEJsruF2mOhSFKGSpDZ2p/Ckcnnk84xzotL9L51+0PN1Rb34bsNpl59MVwlTinGwct9hjge/ORXp0I1BMh6/t0CS+p+zXNtUJyGr/o7VglOG/wjzfLsVe9QdZeRzBYH5qWImxtPJcSR0vge/wDa6y0qm1N6dgN6eDX3U20G44ZGEhI47e+c5zznNYmlNTMajcuYjRpLLcGUuL4jqcIeKSQVIPqMg/oQfWozr22I0rpByRpWLIilDjSHI8FtakLQTtJKEHIwDnckZyBnIzU+t6UCDGDTCozYbTtYKQktjAwnA4GO2Kntc4u0kWsql7WBpeMgnF98d1k0pStq0JSlKIlKUoiUpSiJSlKIlKUoiUpSiKnPtBaEm6iXZL5Z4RmS7cXGpDLePEcZXggpB/EUqT27+ZWM1AkKLGlZMJ9qQzN3eZh1haFj9CK6gpgVXVnDm1Tg/VYq1oeKvo2aNNxv2XEkll9Exh9KXGENr3lxbR2lIHKeRhWQcY+ftXTXRfVcXUekozDSfBlQEJjuMlWcJT5QR7jjH6VqOrukL7qPUdrfjQ0XOxx45QYSbh8GtLxVytSihQKduBx5u/vW56c6Nk2Oc7cZ7MCCr4cQotut61ONR2QsrJW4sBTrilHJUQP7k1uooHwB0bjdvTvf3v6dllX1kdVGHWs7372U/qEdSOnVm1nEfkyYTK761DcYgy3HFpDKyCUEhJwQFEHkGpq44hpBW4tKEDupRwBWsvGoLPZ2kuXW6wYaFHCS++lG76ZPNSXWtZyqmag4Fm64jhSZMWU/bp7Tka5xnFMOt4BKHEnBSR9fUdxWbpjUlysmv7TPYU4t6M6Q40pWAWyMLSfQAj5e1WF1sVpW66rh6h0zdYki5KSGJ7SAra4kDyOhQTgqAG088jb/AC8wu3MP6g1bbIVqhF6UrcTtCUreCElQB3EAAd+T7ewrnpGiKciLOMea62FzpqcGbGcg4wrMvHXTUSHw3a7LagVq2NofccWcntkjAq5Om+qW9Y6Ot15SGkvPJKJDbSiUtupO1aeee4yM+hHfvXJOq4smxXJMaezi5pUENw2nEPOLcVwE/wAMqwc+mc5wAKnXQrROvLD1Qiy75ZpUC0JZdDhD7fg+Zvy+VKzlWQB6kevap9DNO/8A8iq+JU9NGP7OPrhdRUoKVaKkSqd+0Drh2yRI+nra6W5k9suyHB3bYztwPmsgjPoEn3FXFXKPVax3LUP2i12RO5oT2YymHFZwlkN4WofIKS5+oqPVF3KIbuplAGGYF+wytLpPTF71LNQ5p2K8H2VhQmoX4QZV6K8TuDx6ZPHar/6T9OHdIb5t3lxpl3WhxrxIzIaSG1qCylRwC4dwyCcYyQAKlcKNZtFaabb8RmDbIiMFx1QGT7k+qifb6Cq7u/XmxQJRDNrucqEg+eSgIThPqoIUcn+1RqeOOjw93xFTKmonr78pnwj3k/hXFUPu/TPRt1X4krT0FDudxXGSY6lH5lspJ/WpVCktTYjEqMsLYeQlxtY/MlQyD+xr2qyBIyFTFoOCFVWkdOfdl6vsWyS1W+6wJJCG3SXWn4awFNBSSckJ8wCwcghQyeRWk6zdQNU6RhxbepVsjy7i2sokQt63GEpKQVBKxtyd2Bn5+1WlqCxKmymLlbXxEu8ZJQ28RlLiDyW3B6pz+x59waP+0hbrtdbXa7q/ZpTL9t8VuStn+Myple07wpPIAKfzAcE96yqpHPiLm7/X0W+khi5zXbDt0+S12j7Pp6T0i1LenZTczWMdLlzNwdUVTGFN+ZlaVK8wGUjJHBJIORxWt+zLCh3rXt8lXtKZs5yGt1XxI8TxVLUAtSs/iPJHPuaiNouCr5pzTto2+C/HuPwaJI3AyIshaQpkAcLAWdxyePTvWTcol+6KdS2JK2lvRm1q+Hf24bmMHgjPosA8p7g/Ig1UNJLWk5tureRgBcL21be+3vKxep1ka0X1TuEOEz8JCZfblRQ2CAhpYChtz6A7h/pxVw9dZbOo+g9kvMnwly1SIrqVoOQHFApWAR6EFXH/AIqr+oN1X1S163cLa5FjQFstRGnJD6UiOgZJU9zlPmWvnGMY71roOnNay7a/pqPbbhebA1NLzbttWFMeKkFO9ClgApIPY49D6Ua8a3aM36I6MmNhkxbr07HPyV1fZqc+7ekd4nXEgQG5L7+VHjw0tJ3fpkGqi6GWp+89R7GYzavCiOCY6QOG0J5AP64H1Iq3XdEavvfT626SixI2lrIlKUzA7JS/Kkc5IOwFKUk8kBRJ4GcZBsjp3oW06ItHwltQXHnOX5LgG90/9h8q2iIyaQRYBRzUNi1uBuXbD0tdS1I4FfcUHbilT1VJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiLAv1nt9/tEm13mI1MgSUhLrDoylQBBH6ggEH0IrnDq70Vj6YiO6h0Uy793MJBl20qU6W0+rrZOVEDupJzgZI7Yrp6lYSRiRpa5bYZnQuDmlcNW+HNlxg/EgT5DBOA5HiOugn2BQk81tNP6X6izZzg05p662wutllUqWj4U7D+Ibl4IBx6Amu0MH3r6B71Ci4dGw3JurGbi8kgs0WCprpJ0UjaTnNXvUUlu53xHmaCEnwY6jxuTnlasfmOMZ4HrVy0pU5rAwWaqySR0jtTilKUrJYJVX9bo861w7ZrKwoQLvZHFAlaNyVx3PKtKh3IyEnjkc4xmrQr8PNodaW26hK21gpUlQyFA9wR7Vg9utpC2RP5bw4i65E151Ema2lxVymkxIsVsBMZDpWkufmcPA57Aew+pqMXSSiGwrxWi4oDlGQMfI1J9NdPpl66w6s0+24i3s2yQ8+2pTZWlLal7mQBkflWnHPz5xViRfs+pfeAvN/UuNnzNxY+xah/nUo4/9tUb6OWWXU7K6aOvp4IQ1pt2FlKvs3X52+9K4BfYdaMF1yChTnPiIQRsIPqAlQT9UmrQ9KwLDaINhs8S12mOiNBioDbTSeyR9TySTkknkkk1n1etFgAuXe7U4u7rlbrDrC+ResN2j2u93GGxBbYYQ0xIKW8lsOKOz8JPnHcelYUrXuq57Cm5V/lqbUnYpCUoQFDHIOE1YOq+g0m9awu18Z1OlsXB8vlp6D4hb4A2hQcTkAAAcfvUA1j0/1Jo+K7Ilx2ZcBvlUyKCtKR7rSeU/XGB71S10dRqLm3suj4bLSlgY+2rxH7Wp0no6frnUjNthynYiWkeK7NSjf8KlP4MDI5KsAAEep9Kvl7pO9d7A1adW6wvl5itqC9mGmkkjtnylRx81Gq3+y9fpLusb7bC4pcRyKmQRgEBxKsA/Lgn+1dMjtUuhgaIrHdQOJVL+f8OB0VeWnoxoC2KaW3pmFIeQQfElAvFR9yFHb+gGPlVgtIQ02httCUNoASlKRgADsAK/VKsAABYKqJLjcpSlK9XiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlDSlEVFdak3rR2sYOsdNOFgTGkw52U723FIJKA4k+hBIBGDx3Hqt/2gGVMtsy9PS3bieCmI6koUfcbsEfTn61d06HGnxHYs1ht+O6Nq23E7kqHzBrXWjTNks7pctVpgxHD+dllKVfv3qK6KUSFzHWBU9lRAYgyVlyOu3v6rQQ9bXNdt+Pm6L1Awxx5W0tuu/wD6woL/AGFb/TepLXqWCqXZpSZDTay06nBStpY7oWg4KVfIitvgZzWgumkbVOuirolt2HdVJCVTIbpacWAOAvHC8em4HFSGNIPxOuoz3sfs23l/P7W/J+lV/wBSNauWH7tatKbZPU9OEacy68NzTJHm8uRz2HP7H0wLg3crbqqNZ7BrC4SLm8jxXYdyDbraW8HC94QCkkg8DOcenetnZ+nEBqc/Ov8AIN5mPlSnUuspRH3KOSUtc4z68kE84zWLpXtfaNod57fQ397qFUc9pDIm75udrZ26nby8VEOhlhtUPWetJ2n4r7NpLiG2FuJ4KlFSltoP8qNreB/UauwdqiTzd5s93RBsFvYctT6C4FOr2NxXM+YcchJ4UEgHJJGUitrphq8s2sI1DIjyJ29RK2B5dvGPQfP0rTTuIHLINxuenvOFuLpPhEp1EjJG2PstxSlKlL1KUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURKUpREpSlESlKURY5hRTOTNMZgzEt+CHy2PECM527u+M847VkYpSi9JvumB7CmB7UpReJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIlKUoiUpSiJSlKIv/9k="}],"literature":{"PUB00014304":{"PMID":12003496,"ISBN":null,"volume":"8","issue":"3","year":2002,"title":"A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA.","URL":null,"raw_pages":"370-81","medline_journal":"RNA","ISO_journal":"RNA","authors":["Xing F","Martzen MR","Phizicky EM."],"DOI_URL":"http://dx.doi.org/10.1017/S1355838202029825"}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":370,"interactions":0,"matches":47750,"pathways":0,"proteins":46157,"proteomes":21293,"sets":1,"structural_models":{"alphafold":33123},"structures":15,"taxa":34157},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":28367},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1vhn","name":"Crystal structure of a putative flavin oxidoreductase with flavin"}}}