{"metadata":{"accession":"PF01205","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR001498","hierarchy":null,"name":{"name":"Impact N-terminal domain","short":"Impact_N"},"description":[{"text":"<p>This entry represents the N-terminal domain of the Impact proteins. The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis [[cite:PUB00161305],[cite:PUB00158485]]. It is evolutionary conserved from eukaryotes to archaea [[cite:PUB00046141]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00158486":{"PMID":21239490,"ISBN":null,"volume":"286","issue":"12","year":2011,"title":"Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.","URL":null,"raw_pages":"10341-55","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Sattlegger E","Barbosa JA","Moraes MC","Martins RM","Hinnebusch AG","Castilho BA."],"DOI_URL":"https://doi.org/10.1074/jbc.M110.171587"},"PUB00158484":{"PMID":15126500,"ISBN":null,"volume":"279","issue":"29","year":2004,"title":"YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.","URL":null,"raw_pages":"29952-62","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Sattlegger E","Swanson MJ","Ashcraft EA","Jennings JL","Fekete RA","Link AJ","Hinnebusch AG."],"DOI_URL":"https://doi.org/10.1074/jbc.M404009200"},"PUB00161305":{"PMID":23447528,"ISBN":null,"volume":"288","issue":"15","year":2013,"title":"IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.","URL":null,"raw_pages":"10860-9","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Roffe M","Hajj GN","Azevedo HF","Alves VS","Castilho BA."],"DOI_URL":"https://doi.org/10.1074/jbc.M113.461970"},"PUB00046141":{"PMID":11116084,"ISBN":null,"volume":"10","issue":"12","year":2000,"title":"Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.","URL":null,"raw_pages":"1878-89","medline_journal":"Genome Res","ISO_journal":"Genome Res.","authors":["Okamura K","Hagiwara-Takeuchi Y","Li T","Vu TH","Hirai M","Hattori M","Sakaki Y","Hoffman AR","Ito T."],"DOI_URL":"http://dx.doi.org/10.1101/gr.139200"},"PUB00158485":{"PMID":15937339,"ISBN":null,"volume":"280","issue":"31","year":2005,"title":"IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.","URL":null,"raw_pages":"28316-23","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Pereira CM","Sattlegger E","Jiang HY","Longo BM","Jaqueta CB","Hinnebusch AG","Wek RC","Mello LE","Castilho BA."],"DOI_URL":"https://doi.org/10.1074/jbc.M408571200"}},"set_info":{"accession":"CL0329","name":"S5"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":121,"interactions":0,"matches":18629,"pathways":0,"proteins":18592,"proteomes":16361,"sets":1,"structural_models":{"alphafold":12878},"structures":5,"taxa":26223},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":518,"alignment:full":10405},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2cve","name":"Crystal structure of a conserved hypothetical protein TT1547 from thermus thermophilus HB8"}}}