{"metadata":{"accession":"PF01169","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR001727","hierarchy":null,"name":{"name":"Divalent cation/proton antiporter GDT1","short":"GDT1"},"description":[{"text":"<p>This entry, previously known as UPF0016, represents the budding yeast Divalent cation/proton antiporter GDT1 and its homologue, the human TMEM165 that are functionally related and form a new group of Golgi-localised cation/Ca(2+) exchangers. Budding yeast GDT1 is a Golgi-localised calcium transporter required for stress-induced calcium signalling and protein glycosylation [[cite:PUB00079030]]. TMEM165, also a Golgi protein, transports Ca2+ and Mn2+, which are both required for proper protein glycosylation in cells [[cite:PUB00079031],[cite:PUB00152812]]. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00079030":{"PMID":27075443,"ISBN":null,"volume":"6","issue":null,"year":2016,"title":"Yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signaling and protein glycosylation.","URL":null,"raw_pages":"24282","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Colinet AS","Sengottaiyan P","Deschamps A","Colsoul ML","Thines L","Demaegd D","Duchene MC","Foulquier F","Hols P","Morsomme P."],"DOI_URL":"http://dx.doi.org/10.1038/srep24282"},"PUB00079031":{"PMID":24530912,"ISBN":null,"volume":"445","issue":"2","year":2014,"title":"The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca(2+) ATPase (SPCA1).","URL":null,"raw_pages":"417-21","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Reinhardt TA","Lippolis JD","Sacco RE."],"DOI_URL":"http://dx.doi.org/10.1016/j.bbrc.2014.02.020"},"PUB00152812":{"PMID":32047108,"ISBN":null,"volume":"295","issue":"12","year":2020,"title":"The human Golgi protein TMEM165 transports calcium and manganese in yeast and bacterial cells.","URL":null,"raw_pages":"3865-3874","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Stribny J","Thines L","Deschamps A","Goffin P","Morsomme P."],"DOI_URL":"https://doi.org/10.1074/jbc.RA119.012249"}},"set_info":{"accession":"CL0292","name":"LysE"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":121,"interactions":0,"matches":25173,"pathways":0,"proteins":13378,"proteomes":9440,"sets":1,"structural_models":{"alphafold":9762},"structures":0,"taxa":17433},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":378,"alignment:full":15231},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}