{"metadata":{"accession":"PF01060","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR001534","hierarchy":null,"name":{"name":"Transthyretin-like family","short":"TTR-52"},"description":[{"text":"<p>TTR-52 was called family 2 in [[cite:PUB00001984]], and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure [[cite:PUB00109168]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00001984":{"PMID":9417907,"ISBN":null,"volume":"46","issue":"2","year":1997,"title":"Analysis of protein domain families in Caenorhabditis elegans.","URL":null,"raw_pages":"200-16","medline_journal":"Genomics","ISO_journal":"Genomics","authors":["Sonnhammer EL","Durbin R."],"DOI_URL":"http://dx.doi.org/10.1006/geno.1997.4989"},"PUB00109168":{"PMID":22713871,"ISBN":null,"volume":"26","issue":"12","year":2012,"title":"Structural study of TTR-52 reveals the mechanism by which a bridging molecule mediates apoptotic cell engulfment.","URL":null,"raw_pages":"1339-50","medline_journal":"Genes Dev","ISO_journal":"Genes Dev","authors":["Kang Y","Zhao D","Liang H","Liu B","Zhang Y","Liu Q","Wang X","Liu Y."],"DOI_URL":null}},"set_info":{"accession":"CL0287","name":"Transthyretin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":133,"interactions":0,"matches":5108,"pathways":0,"proteins":4864,"proteomes":114,"sets":1,"structural_models":{"alphafold":4620},"structures":1,"taxa":297},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":95,"alignment:full":3950},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}