{"metadata":{"accession":"PF01042","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR006175","hierarchy":null,"name":{"name":"Endoribonuclease L-PSP","short":"Ribonuc_L-PSP"},"description":[{"text":"<p>Endoribonuclease active on single-stranded mRNA.  Inhibits protein synthesis by cleavage of mRNA [[cite:PUB00007949]].  Previously thought to inhibit protein synthesis initiation [[cite:PUB00002939]]. This protein may also be involved in the regulation of purine biosynthesis [[cite:PUB00007948]]. YjgF (renamed RidA) family members are enamine/imine deaminases. They hydrolyze reactive intermediates released by PLP-dependent enzymes, including threonine dehydratase [[cite:PUB00064878]]. YjgF also prevents inhibition of transaminase B (IlvE) in Salmonella [[cite:PUB00109184]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00109184":{"PMID":14729707,"ISBN":null,"volume":"186","issue":"3","year":2004,"title":"Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium.","URL":null,"raw_pages":"803-10","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Schmitz G","Downs DM."],"DOI_URL":null},"PUB00064878":{"PMID":22094463,"ISBN":null,"volume":"287","issue":"5","year":2012,"title":"Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.","URL":null,"raw_pages":"3454-61","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Lambrecht JA","Flynn JM","Downs DM."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M111.304477"},"PUB00007949":{"PMID":10400702,"ISBN":null,"volume":"274","issue":"29","year":1999,"title":"Ribonuclease activity of rat liver perchloric acid-soluble protein, a potent inhibitor of protein synthesis.","URL":null,"raw_pages":"20688-92","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Morishita R","Kawagoshi A","Sawasaki T","Madin K","Ogasawara T","Oka T","Endo Y."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.274.29.20688"},"PUB00007948":{"PMID":10368157,"ISBN":null,"volume":"181","issue":"12","year":1999,"title":"A role for a highly conserved protein of unknown function in regulation of Bacillus subtilis purA by the purine repressor.","URL":null,"raw_pages":"3810-5","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Rappu P","Shin BS","Zalkin H","Mantsala P."],"DOI_URL":"http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=10368157&action=stream&blobtype=pdf"},"PUB00054810":{"PMID":19899170,"ISBN":null,"volume":"78","issue":"3","year":2010,"title":"Mycobacterium tuberculosis Rv2704 is a member of the YjgF/YER057c/UK114 family.","URL":null,"raw_pages":"773-8","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Thakur KG","Praveena T","Gopal B."],"DOI_URL":null},"PUB00002939":{"PMID":8530410,"ISBN":null,"volume":"270","issue":"50","year":1995,"title":"Isolation and characterization of a novel perchloric acid-soluble protein inhibiting cell-free protein synthesis.","URL":null,"raw_pages":"30060-7","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Oka T","Tsuji H","Noda C","Sakai K","Hong YM","Suzuki I","Munoz S","Natori Y."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.270.50.30060"}},"set_info":{"accession":"CL0534","name":"YjgF-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":403,"interactions":0,"matches":76763,"pathways":0,"proteins":74014,"proteomes":19722,"sets":1,"structural_models":{"alphafold":48953},"structures":76,"taxa":31830},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":39692},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"9bjy","name":"Crystal structure of RidA family protein PA5083 from Pseudomonas aeruginosa with TMAO bound"}}}